Dysregulated antibody immunity leads to lifelong susceptibility to infections and limited vaccine responses, most strikingly in primary immunodeficiency disorders, such as Common Variable Immunodeficiency, CVID and, at the other end other spectrum, to overproduction of destructive antibodies in autoimmune disease, such as Sjogren’s syndrome.
Our research programs aim to solve the underlying genomic and functional causes of rare diseases of antibody dysregulation. Our discoveries have led to life-saving personalised therapies and care for children and adults living with antibody deficiencies, who had no genetic diagnosis prior to our intervention.
The Immunogenomics Laboratory brings together disciplines of foundational human immunology, clinical genomics and high-resolution single cell-omics and immune profiling to identify and refine our knowledge of the many ways variation in gene expression and immune cell programming can lead to poor immune health. Our goal is to develop novel diagnostics and therapies to close the widening gaps between genomic sequencing, genetic diagnoses and precision care.