Professor Beavis’ team has a significant interest in developing novel CAR T cell technology to enhance their effectiveness in solid cancers, guided by the philosophy that engagement of host immunity is key for effective responses. Their work has been published in leading journals including Nature, Nature Immunology, The Journal of Clinical Investigation and Nature Communications. In Paul’s seminar he will discuss the latest approaches from his team to enhance the efficacy of CAR T cells and the pathway towards clinical translation. One of the CAR T cell technologies developed by his team is set to enter a clinical trial in 2026 with another currently in the developmental phase with the Centre of Excellence in Cellular Immunotherapy.
Paul will also present recently published and unpublished work highlighting strategies under investigation from his group to enhance the efficacy of immune checkpoint blockade through the targeting of myeloid cells.