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About

I am a medical oncologist with a special interest in colorectal cancer.

My research is aimed at understanding the features of colorectal cancer that predict how a patient will experience the disease, such as whether they will respond to therapy and whether they are at risk of recurrence following surgery.

I am also exploring whether a simple blood test could be used for the early detection of cancer, diagnosing tumours before they spread, when the chance of cure is high.

Publications

Selected publications from Prof Jeanne Tie

Burge ME, Espinoza D, Sjoquist KM, Siu DH, Mercieca-Bebber R, Chantrill LA, Karapetis CS, Steer CB, Yip S, Cuff J, Winata S, Tie J, Thaker DA, Srivastav R, Abdi E, Strickland A, Segelov E, Francesconi A, Price T, Ladwa R, Joubert W, Tebbutt NC. AGITG MONARCC: A Randomized Phase 2 Study of Panitumumab Monotherapy and Panitumumab Plus 5-Fluorouracil as First-Line Therapy for Older Patients With RAS and BRAF Wild Type Metastatic Colorectal Cancer. A Study by the Australasian Gastro-Intestinal Trials Group (AGITG). Clinical Colorectal Cancer. 2025;24(2):10.1016/j.clcc.2024.11.003

Tie J, Wang Y, Loree JM, Cohen JD, Espinosa D, Wong R, Price TJ, Tebbutt NC, Lee M, Burge ME, Harris SJ, Lee B, Lynam JF, O’Callaghan CJ, Breadner DA, Bettegowda C, Papadopoulos N, Kinzler KW, Vogelstein B, Gibbs P. ctDNA-guided adjuvant chemotherapy escalation in stage III colon cancer: Primary analysis of the ctDNA-positive cohort from the randomized AGITG dynamic-III trial (intergroup study of AGITG and CCTG).Journal of Clinical Oncology. 2025;43(16_suppl):10.1200/jco.2025.43.16_suppl.3503

McLachlan S-A, Mostafa R, Sharpe L, Burge ME, Day F, Blum RH, Campbell R, Lynam JF, Lee B, Singh MS, Lee M, Chantrill LA, Lundy J, Wong ZW, Wong R, Joshi S, Saqib A, Karikios DJ, Gibbs P, Tie J. Circulating tumor DNA (ctDNA) analysis guiding adjuvant therapy in patients (pts) with colorectal cancer (CRC): Impact on fear of cancer recurrence (FCR).Journal of Clinical Oncology. 2025;43(16_suppl):10.1200/jco.2025.43.16_suppl.11125

Tie J, Wang Y, Lo SN, Lahouel K, Cohen JD, Wong R, Shapiro JD, Harris SJ, Khattak A, Burge ME, Lee M, Harris M, McLachlan S-A, Horvath L, Karapetis C, Shannon J, Singh M, Yip D, Ananda S, Underhill C, Ptak J, Silliman N, Dobbyn L, Popoli M, Papadopoulos N, Tomasetti C, Kinzler KW, Vogelstein B, Gibbs P. Circulating tumor DNA analysis guiding adjuvant therapy in stage II colon cancer: 5-year outcomes of the randomized DYNAMIC trial. Nature Medicine. 2025;31(5):10.1038/s41591-025-03579-w

Kim GY, Tie J, Gibbs P. Letter to the Editor: Are We Asking the Right Question for New Biomarkers – “Ready for Prime Time” Versus Demonstrated Clinical Utility?. Journal of the National Comprehensive Cancer Network. 2025;23(5):10.6004/jnccn.2025.7037

Samnotra V, Ramos-Hernandez N, Faitg T, Srinivasan M, Roy T, Liu A, Zaremba T, Holford C, Smith R, Henry JT, Tie J, Yamamoto N, Serbest G. Abstract CT194: First-in-human, phase 1/2 study of GSK4418959, an oral Werner DNA helicase inhibitor, alone or combined with other anticancer agents in adults with advanced mismatch repair-deficient or microsatellite instability-high solid tumors (SYLVER). Cancer Research. 2025;85(8_Supplement_2):10.1158/1538-7445.am2025-ct194

Siena S, Raghav K, Takashima A, Kato T, Van den Eynde M, Pietrantonio F, Komatsu Y, Kawakami H, Peeters M, Andre T, Lonardi S, Yamaguchi K, Tie J, Castro CG, Strickler JH, Shiose Y, Koga M, Boran A, Haribhai D, Goto H, Barrios D, Abe K, Yoshino T. Abstract 7148: Exploratory biomarker analysis of trastuzumab deruxtecan (T-DXd) treatment for HER2-positive (HER2+) metastatic colorectal cancer (mCRC) in DESTINY-CRC02 (DC-02). Cancer Research. 2025;85(8_Supplement_1):10.1158/1538-7445.am2025-7148

Dunn C, Tie J, Gibbs P. A Call for Improved Guidance to Integrate Modern Biomarkers Into Routine Clinical Care—Piecing the Puzzle Together. JAMA Oncology. 2025;11(4):10.1001/jamaoncol.2024.6479

Lahouel K, Douville C, Diergaarde B, Cohen JD, Grant H, Kuo A, Ansari SK, Wang Y, O’Broin-Lennon AM, Popoli M, Ptak J, Silliman N, Dobbyn L, Nehme N, Tie J, Gibbs P, Papadopoulos N, Kinzler KW, Vogelstein B, Schoen RE, Tomasetti C. A Blood-Based Assay for Detection of Patients with Advanced Adenomas. Cancer Research Communications. 2025;5(4):10.1158/2767-9764.crc-24-0398

Kim GY, Jalali A, Gard G, Yeung JM, Chau H, Gately L, Houli N, Jones IT, Kosmider S, Lee B, Lee M, Nott L, Shapiro JD, Tie J, Thomson B, To YH, Wong V, Wong R, Dunn C, Johns J, Gibbs P. Initial Assessment of Resectability of Colorectal Cancer Liver Metastases Versus Clinical Outcome. Clinical Colorectal Cancer. 2025;24(1):10.1016/j.clcc.2024.10.001

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