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About

Ben leads the Genito-Urinary (GU) research program within the Gibbs Lab at WEHI. His team focuses on generating Real World Evidence (RWE) to change practice in GU cancers.

Ben is also a medical oncologist at Peter MacCallum Cancer Centre where he leads the GU medical oncology group and trials program. He is an Associate Professor at the University of Melbourne. Ben also chairs the Phase 1 Trials Group within Cancer Trials Australia and the Germ Cell Tumour group within ANZUP.

At WEHI, Ben leads multi-national registries in Prostate cancer, Urothelial cancer, Testis cancer and Kidney cancer. Data from these registries have been utilized to describe treatment patterns, identify clinical and tissue-based biomarkers and inform future research strategies. Ben has expanded the out-reach of these registries to Asia, with sites now contributing from Singapore and Korea. Ben is recognized globally for his leadership in RWE in GU cancers. Ben is also internationally recognized as an expert in testicular cancer, utilizing his RWE leadership to drive pragmatic clinical trials aimed at improving long term outcomes for testicular cancer survivors.

Ben also leads the early development of novel therapeutics in GU cancers. He is globally respected for his knowledge and expertise in early phase, first time in human clinical trials. His role within developmental therapeutics is essential in connecting scientists to clinicians and facilitating a bench to bedside and back to bench approach to cancer research.

Publications

Selected publications from A/Prof Ben Tran

Conduit C, Bagrodia A, Hamilton RJ, Feldman DR, Tran B. Optimal Management of Stage II Seminoma: Preventing Harm While Preserving Cure.JCO Oncology Practice. 2025;:10.1200/op-25-00252

Williams C, Inderjeeth A-J, Hong W, McKenzie J, Anton A, Weickhardt A, Wong S, Shapiro J, Parente P, Goh J, Torres J, Smith A, Joshua A, Brown S, Steer C, Johns J, Gibbs P, Tran B, Azad AA. Treatment patterns and outcomes for younger patients with metastatic castration-resistant prostate cancer (mCRPC); An Australian prospective registry study. Clinical Genitourinary Cancer. 2025;23(3):10.1016/j.clgc.2025.102345

Weickhardt AJ, Foroudi F, Lawrentschuk N, Xie J, Ko Y-A, Sidhom M, Pal A, Grimison PS, Zhang AY, Ng S, Tang C, Hovey EJ, Chen C, Hruby G, Guminski AD, Oakes SR, Conduit C, Tran B, Davis ID, Hayne D. Pembrolizumab (pembro) with chemoradiotherapy (CRT) as treatment for muscle-invasive bladder cancer (MIBC): Long-term follow up of secondary endpoints of efficacy including overall survival of the PCR-MIB phase II clinical trial (ANZUP 1502).Journal of Clinical Oncology. 2025;43(16_suppl):10.1200/jco.2025.43.16_suppl.4577

Buteau JP, Kostos LK, Jackson P, McIntosh L, Alipour R, Akhurst TJ, Eifer M, Emmerson B, Haskali MB, Jewell K, Kashyap R, Kong G, Murphy D, Ravi Kumar AS, Saghebi J, Sandhu S, Tran B, Xie J, Azad A, Hofman MS. First-in-human results of terbium-161[ 161 Tb]Tb-PSMA-I&T radioligand treatment in patients with metastatic castration-resistant prostate cancer (VIOLET): A single-centre, single-arm, phase I/II study.Journal of Clinical Oncology. 2025;43(16_suppl):10.1200/jco.2025.43.16_suppl.5010

Tran B, Frentzas S, Lemech CR, Millward M, Day D, Desai J, Latifi A, Wabnitz P, Kearney P, Galkin AV. Abstract 5850: AXA-042, a systemically administered TLR2/6 agonist, demonstrates innate immune engagement and Th1 polarization in patients with advanced solid tumors. Cancer Research. 2025;85(8_Supplement_1):10.1158/1538-7445.am2025-5850

Conduit C, Hutchinson AD, Leonard M, O.’Haire S, Moody M, Thomas B, Sim I, Hong W, Ahmad G, Lawrentschuk N, Lewin J, Tran B, Dhillon HM. An exploration of testicular cancer survivors’ experience of ejaculatory dysfunction following retroperitoneal lymph node dissection—a sub-study of the PREPARE clinical trial. Journal of Cancer Survivorship. 2025;19(2):10.1007/s11764-023-01489-9

Eifer M, Sutherland DEK, Goncalves I, Buteau JP, Au L, Azad AA, Emmett L, Kong G, Kostos L, Ravi Kumar AS, Kwan EM, Medhurst E, Sandhu S, Tran B, Wyatt AW, Hofman MS. Therapy-Related Myeloid Neoplasms After [177Lu]Lu-PSMA Therapy in Patients with Metastatic Castration-Resistant Prostate Cancer: A Case Series.Journal of Nuclear Medicine. 2025;66(4):10.2967/jnumed.124.268640

Udovicich C, Bressel M, Manji J, Ali M, Au L, Azad AA, Buteau JP, Chander S, Chang D, Eapen R, Lawrentschuk N, Levy SM, Moon D, Murphy DG, Perera M, Shaw M, Spain L, Tran B, Hofman MS, Siva S. PSMA-Guided Metastasis-Directed Therapy for Oligometastatic Renal Cell Carcinoma: The Proof-of-Concept PEDESTAL Study.Journal of Nuclear Medicine. 2025;66(4):10.2967/jnumed.124.268639

Kostos L, Buteau JP, Kong G, Tran B, Haskali MB, Fahey M, Crumbaker M, Emmett L, Hofman MS, Azad AA. Clinical Trial Protocol for LuCAB: A Phase I-II Trial Evaluating Cabazitaxel in Combination with [177Lu]Lu-PSMA-617 in Patients with Metastatic Castration-Resistant Prostate Cancer.Journal of Nuclear Medicine. 2025;66(4):10.2967/jnumed.124.269252

Abdul Aziz N, Ng K, Alifrangis C, Tran B, Conduit C, Liow ECH, Ackerman C, Georgescu R, Jamal T, Relton C, Mayer E, Nicol D, Cazzaniga W, Huddart RA, Reid AH, Shamash J, Rajan P. THERATEST: A multi-centre observational cohort feasibility study of de-escalation therapies for stage II seminoma.Journal of Clinical Oncology. 2025;43(5_suppl):10.1200/jco.2025.43.5_suppl.tps651

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