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About

Ben leads the Genito-Urinary (GU) research program within the Gibbs Lab at WEHI. His team focuses on generating Real World Evidence (RWE) to change practice in GU cancers.

Ben is also a medical oncologist at Peter MacCallum Cancer Centre where he leads the GU medical oncology group and trials program. He is an Associate Professor at the University of Melbourne. Ben also chairs the Phase 1 Trials Group within Cancer Trials Australia and the Germ Cell Tumour group within ANZUP.

At WEHI, Ben leads multi-national registries in Prostate cancer, Urothelial cancer, Testis cancer and Kidney cancer. Data from these registries have been utilized to describe treatment patterns, identify clinical and tissue-based biomarkers and inform future research strategies. Ben has expanded the out-reach of these registries to Asia, with sites now contributing from Singapore and Korea. Ben is recognized globally for his leadership in RWE in GU cancers. Ben is also internationally recognized as an expert in testicular cancer, utilizing his RWE leadership to drive pragmatic clinical trials aimed at improving long term outcomes for testicular cancer survivors.

Ben also leads the early development of novel therapeutics in GU cancers. He is globally respected for his knowledge and expertise in early phase, first time in human clinical trials. His role within developmental therapeutics is essential in connecting scientists to clinicians and facilitating a bench to bedside and back to bench approach to cancer research.

Publications

Selected publications from Prof Ben Tran

Tran B, Voskoboynik M, Kim S-W, Lemech C, Carcereny E, Rha SY, Ahn M-J, Felip E, Lee KH, Álvarez EC, Yang JC-H, Ascierto PA, Pulla MP, Kondo S, Kuboki Y, Freeman D, Song X, Blando J, Eck S, Song FJ, Tang Z, Kuziora M, Gainer SD, Mitchell P, Asare J, Ayyoub A, Achour I, Subramaniam DS, Im S-A. Safety, Pharmacokinetics, Pharmacodynamics, and Preliminary Efficacy from a First-in-Human Study of Volrustomig, a Novel PD-1/CTLA-4 Bispecific Antibody. Clinical Cancer Research. 2026;32(14):10.1158/1078-0432.ccr-25-3447

To V, Thio N, Castle R, Macdonald S, Molden-Hauer T, Wells J, McMahon R, Bressel M, Tran B, Azad AA, Moon D, Appu S, Wong L-M, Murphy DG, Cuff K, Pryor D, Spain L, Au L, D’Souza C, Neeson PJ, Siva S. Dynamic immune profiling predicts response to radiation plus anti-PD-1 therapy in oligometastatic renal cell carcinoma. Nature Communications. 2026;:10.1038/s41467-026-74255-x

Panasci J, Park CL, Tran B, Siu LL. Advances in cancer immunotherapy: adoptive cell therapy and immune cell engagers in solid tumours. British Journal of Cancer. 2026;135(1):10.1038/s41416-026-03450-w

Pan HYC, Homewood D, Lucas H, Dittmer B, Teh J, O’Brien JS, Liu J, Tran B, Chee J, Churchill JA, Lawrentschuk N, Corcoran NM. The Australian Penile Cancer Clinical Registry: a comprehensive national approach to data collection. BJU International. 2026;138(Suppl 2):10.1111/bju.70188

Sherry AD, To V, D’souza C, Kiany S, Thio N, Liu S, Sun X, Castle B, Macdonald S, Choi H, Seo A, Hara K, Pryor D, Azad A, Tran B, Au L, Spain L, Ludmir EB, Jonasch E, Tannir NM, Msaouel P, Neeson P, Haymaker C, Tang C, Siva S. Metastasis-directed Therapy With or Without Pembrolizumab for Oligometastatic Clear Cell Renal Cell Carcinoma: Pooled Analysis of Two Prospective Single-arm Phase 2 Trials. European Urology. 2026;90(1):10.1016/j.eururo.2026.03.024

Tran B, Dorff T, Richey M, Hankinson E, Olsen P, Karwa S, Sharpe J, Braunlin M, Kim C. Treatment Patterns and Survival Outcomes in a Real-World Cohort of Lutetium 177 Vipivotide Tetraxetan (LuPSMA)-Experienced Patients with Metastatic Castration-Resistant Prostate Cancer (mCRPC). Clinical Genitourinary Cancer. 2026;:10.1016/j.clgc.2026.102609

Xu YE, Hitchen N, Kamanat BV, O’Haire S, Harris W, Chan KH, Wilson M, Koyama T, Prasongsook N, Thambamroong T, Kho BP, Ting FIL, Vo TTP, Kim J, Voon P-J, Heong VYM, Ueno NT, Tran B, Tan DSW, Loong HHF. 177RO Regulatory approval delays for pembrolizumab and trastuzumab deruxtecan across the Asia-Pacific region. ESMO Open. 2026;11:10.1016/j.esmoop.2026.107978

Kashyap R, Buteau JP, Papa N, Ayati N, Eifer M, Betech-Antar V, Akhurst T, Alipour R, Kong G, Saghebi J, Ravi Kumar AS, Cardin A, Sandhu S, Tran B, Azad AA, Murphy DG, Hofman MS. Prognostic Value of Restaging [18F]FDG PET/CT in Patients with Metastatic Castration-Resistant Prostate Cancer Undergoing [177Lu]Lu-PSMA-617 Therapy.Journal of Nuclear Medicine. 2026;:10.2967/jnumed.126.272531

Chow KVC, Conduit C, O’Haire S, Kuchel A, Wong S, Grimison P, Weickhardt A, Pranavan G, Lynam J, Bastick P, Goh J, Sengupta S, Smith A, Liow E, Campbell D, Wong M, Zlatic K, Gibbs P, Tran B, Gan CL. Extracranial, Extragonadal Germ Cell Tumors: A Multicenter Australian Case Series. Asia-Pacific Journal of Clinical Oncology. 2026;22(3):10.1111/ajco.70083

Dorff TB, Appleman LJ, Lin C-C, Lee JL, Tran B, Fischer S, Danila D, Gokani P, Gallent B, Pook DW. XALience: A phase 3, open-label, multicenter, randomized study of xaluritamig plus abiraterone vs investigator’s choice in patients with chemotherapy-naïve metastatic castration-resistant prostate cancer.Journal of Clinical Oncology. 2026;44(16_suppl):10.1200/jco.2026.44.16_suppl.tps5144

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