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About

Ben leads the Genito-Urinary (GU) research program within the Gibbs Lab at WEHI. His team focuses on generating Real World Evidence (RWE) to change practice in GU cancers.

Ben is also a medical oncologist at Peter MacCallum Cancer Centre where he leads the GU medical oncology group and trials program. He is an Associate Professor at the University of Melbourne. Ben also chairs the Phase 1 Trials Group within Cancer Trials Australia and the Germ Cell Tumour group within ANZUP.

At WEHI, Ben leads multi-national registries in Prostate cancer, Urothelial cancer, Testis cancer and Kidney cancer. Data from these registries have been utilized to describe treatment patterns, identify clinical and tissue-based biomarkers and inform future research strategies. Ben has expanded the out-reach of these registries to Asia, with sites now contributing from Singapore and Korea. Ben is recognized globally for his leadership in RWE in GU cancers. Ben is also internationally recognized as an expert in testicular cancer, utilizing his RWE leadership to drive pragmatic clinical trials aimed at improving long term outcomes for testicular cancer survivors.

Ben also leads the early development of novel therapeutics in GU cancers. He is globally respected for his knowledge and expertise in early phase, first time in human clinical trials. His role within developmental therapeutics is essential in connecting scientists to clinicians and facilitating a bench to bedside and back to bench approach to cancer research.

Publications

Selected publications from A/Prof Ben Tran

Lemelin A, Zarba M, Takemura K, Wells JC, Chehade REH, Donskov F, Porta C, De Velasco G, Davis ID, Wood LA, Pal SK, Hansen AR, Tran B, Bjarnason GA, Li H, Kanesvaran R, Powles T, McKay RR, Choueiri TK, Heng DYC. Attrition Rates in Metastatic Renal Cell Carcinoma (mRCC) Following First Line Immunotherapy-Based Treatment: Results From the International mRCC Database Consortium (IMDC). Clinical Genitourinary Cancer. 2026;24(1):10.1016/j.clgc.2025.102484

Moody SC, Fietz D, Nathaniel B, Frydenberg M, Tran B, Schuppe H, Loveland KL. Spatial transcriptomics mapping of immune cell and TGFβ signalling pathway heterogeneity in testicular germ cell tumours. Andrology. 2026;14(1):10.1111/andr.70100

Chen DC, Buteau JP, Papa N, Akhurst T, Alipour R, Bollampally N, Cardin A, Eifer M, Casanueva Eliceiry S, Jackson P, Jewell K, Kashyap R, Kong G, Kostos L, Ravi Kumar A, McIntosh L, Medhurst E, Saghebi J, Sandhu S, Murphy DG, Tran B, Azad AA, Hofman MS. Prognostic Value of Initial Imaging and PSA Change with [177Lu]Lu-PSMA-617 Radiopharmaceutical Therapy in Patients with Metastatic Castration-Resistant Prostate Cancer: A ProsTIC Registry Analysis.Journal of Nuclear Medicine. 2025;66(12):10.2967/jnumed.125.270804

Anton A, Joung JY, Han H, Kanesvaran R, Weickhardt AJ, Wong SSL, Azad A, Shapiro J, Brown S, Goh JCH, Parente P, Oliveira N, Torres J, Liow ECH, Smith A, Steer C, Gibbs P, Tran B. 503P Treatment intensification in metastatic hormone sensitive prostate cancer (mHSPC), real-world adoption of combination therapies in Australia and Asia. Annals of Oncology. 2025;36:10.1016/j.annonc.2025.10.398

Bainomugisa CK, Dasgupta P, Cameron JK, Tran B, Cramb SM, Baade PD. Spatial patterns of testicular cancer diagnosis in Australia, 2010-2019. Spatial and Spatio-temporal Epidemiology. 2025;55:10.1016/j.sste.2025.100745

Shahnam A, Hitchen N, Manoharan S, John T, Mileshkin L, Solomon B, Sandhu S, Luen SJ, Desai J, Tran B. Impact of age and comorbidity on safety outcomes in phase 1 trial participants for metastatic solid malignancies. Journal of Geriatric Oncology. 2025;16(8):10.1016/j.jgo.2025.102721

Kostos L, Buteau JP, Xie J, Cardin A, Akhurst T, Alipour R, Au L, Chan J, Chin KY, Emmerson B, Furic L, Garcia Q, Hamilton AJ, Haskali MB, Jackson PA, Kashyap RK, Kong G, MacFarlane L, Murphy DG, Parker BS, Ravi Kumar AS, Saghebi J, Wang Y, Tran B, Azad AA, Hofman MS. Lutetium-177 [177Lu]Lu-PSMA-I&T plus radium-223 in patients with metastatic castration-resistant prostate cancer (AlphaBet): an interim analysis of the investigator-initiated, single-centre, single-arm, phase 1/2 trial. The Lancet Oncology. 2025;26(11):10.1016/s1470-2045(25)00559-5

Daneshmand S, Zaucha R, Catto JWF, Tran B, Master V, Lotan Y, Pignot G, Tubaro A, Shimizu N, Vasdev N, Lee EK, Procopio G, Galanternik F, Crow L, Deprince K, Naini V, Triantos S, Baig M, Zhu W, Maranchie JK. Erdafitinib in Patients with High- and Intermediate-risk Non–muscle-invasive Bladder Cancer: Final Analysis of THOR-2 Study. European Urology. 2025;:10.1016/j.eururo.2025.09.4152

Eid M, Semaan K, Xie W, Chehade REH, Ascione L, Maj D, Zarba M, Wells JC, Wood L, Tran B, Angel M, Pal SK, Lee J-L, Takemura K, Kollmannsberger CK, Templeton AJ, Bjarnason GA, Ruiz JM, Heng D, Choueiri TK. 50Clinical characteristics, determinants and subsequent therapy of primary refractory metastatic renal cell carcinoma (mRCC): an international metastatic database consortium (IMDC) study. The Oncologist. 2025;30(Supplement_2):10.1093/oncolo/oyaf276.051

Grande E, Bellmunt J, Hussain SA, Al Mansour MM, Bamias A, Barthélémy P, Benjamin DJ, Blais N, Bourlon MT, Castellano D, Danchaivijitr P, Lazzaro MF, Giannatempo P, Guerrero-Ramos F, Iacovelli R, Ivanyi P, Jung EH, Kanesvaran R, Manneh R, Marinho JC, Matsubara N, Merseburger AS, Mukherji D, Park CH, Tran B, da Trindade KM, Ürün Y, Kamat AM, Birtle AJ. Guiding first-line treatment decisions in advanced urothelial carcinoma: a global survey. The Oncologist. 2025;30(10):10.1093/oncolo/oyaf333

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