I am interested in the field of gene-editing and the generation of mouse models. Our group has used CRISPR gene-editing technology to generate highly complex mouse models and we are currently investigating the use of various CRISPR enzymes to increase the efficiency and speed of generating these models.


Selected publications from Dr Andrew Kueh

Aubrey, B.J., Kelly, G.L., Kueh, A.J., Brennan, M.S., O’Connor, L., Milla, L., Wilcox, S., Tai, L., Strasser, A., and Herold, M.J. (2015). An inducible lentiviral guide RNA platform enables the identification of tumor-essential genes and tumor-promoting mutations in vivo. Cell Rep 10, 1422-1432. 10.1016/j.celrep.2015.02.002.

Deng, Y., Diepstraten, S.T., Potts, M.A., Giner, G., Trezise, S., Ng, A.P., Healey, G., Kane, S.R., Cooray, A., Behrens, K., Heidersbach, Kueh, A.J, A.J., Pal, M., Wilcox, S., Tai, L., Alexander, W.S., Visvader, J.E., Nutt, S.L., Strasser, A., Haley, B., Zhao, Q., Kelly, G.L., and Herold, M.J. (2022). Generation of a CRISPR activation mouse that enables modelling of aggressive lymphoma and interrogation of venetoclax resistance. Nat Commun 13, 4739. 10.1038/s41467-022-32485-9.

Lalaoui, N., Boyden, S.E., Oda, H., Wood, G.M., Stone, D.L., Chau, D., Liu, L., Stoffels, M., Kratina, T., Lawlor, K.E., Zaal, K.J.M., Hoffmann, P.M., Etemadi, N., Shield-Artin, K., Biben, C., Tsai, W.L., Blake, M.D., Kuehn, H.S., Yang, D., Anderton, H., Silke, N., Wachsmuth, L., Zheng, L., Moura, N.S., Beck, D.B., Gutierrez-Cruz, G., Ombrello, A.K., Pinto-Patarroyo, G.P., Kueh, A.J., 18. Herold, M.J., Hall, C., Wang, H., Chae, J.J., Dmitrieva, N.I., McKenzie, M., Light, A., Barham, B.K., Jones, A., Romeo, T.M., Zhou, Q., Aksentijevich, I., Mullikin, J.C., Gross, A.J., Shum, A.K., Hawkins, E.D., Masters, S.L., Lenardo, M.J., Boehm, M., Rosenzweig, S.D., Pasparakis, M., Voss, A.K., Gadina, M., Kastner, D.L., and Silke, J. (2020). Mutations that prevent caspase cleavage of RIPK1 cause autoinflammatory disease. Nature 577, 103-108. 10.1038/s41586-019-1828-5.

Janic, A., Valente, L.J., Wakefield, M.J., Di Stefano, L., Milla, L., Wilcox, S., Yang, H., Tai, L., Vandenberg, C.J., Kueh, A.J., Mizutani, S., Brennan, M.S., Schenk, R.L., Lindqvist, L.M., Papenfuss, A.T., O’Connor, L., Strasser, A., and Herold, M.J. (2018). DNA repair processes are critical mediators of p53-dependent tumor suppression. Nat Med 24, 947-953. 10.1038/s41591-018-0043-5.

Kueh, A.J., Pal, M., Tai, L., Liao, Y., Smyth, G.K., Shi, W., and Herold, M.J. (2017). An update on using CRISPR/Cas9 in the one-cell stage mouse embryo for generating complex mutant alleles. Cell Death Differ 24, 1821-1822. 10.1038/cdd.2017.122.

Doerflinger, M., Deng, Y., Whitney, P., Salvamoser, R., Engel, S., Kueh, A.J., Tai, L., Bachem, A., Gressier, E., Geoghegan, N.D., Wilcox, S., Rogers, K.L., Garnham, A.L., Dengler, M.A., Bader, S.M., Ebert, G., Pearson, J.S., De Nardo, D., Wang, N., Yang, C., Pereira, M., Bryant, C.E., Strugnell, R.A., Vince, J.E., Pellegrini, M., Strasser, A., Bedoui, S., and Herold, M.J. (2020). Flexible Usage and Interconnectivity of Diverse Cell Death Pathways Protect against Intracellular Infection. Immunity 53, 533-547 e537. 10.1016/j.immuni.2020.07.004.

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