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About

I am interested in the field of gene-editing and the generation of mouse models. Our group has used CRISPR gene-editing technology to generate highly complex mouse models and we are currently investigating the use of various CRISPR enzymes to increase the efficiency and speed of generating these models.

Publications

Selected publications from Dr Andrew Kueh

Swiderski K, Trieu J, Chee A, Naim T, Brock CJ, Baum DM, Chan AS, Hardee JP, Li W, Kueh AJ, Herold MJ, Murphy KT, Gregorevic P, Lynch GS. Altering phosphorylation of dystrophin S3059 to attenuate cancer cachexia. Life Sciences. 2024;362:10.1016/j.lfs.2024.123343

Kauppi M, Hyland CD, Viney EM, White CA, de Graaf CA, Welch AE, Yousef J, Dagley LF, Emery-Corbin SJ, Di Rago L, Kueh AJ, Herold MJ, Hilton DJ, Babon JJ, Nicola NA, Behrens K, Alexander WS. Cullin-5 controls the number of megakaryocyte-committed stem cells to prevent thrombocytosis in mice. Blood. 2024;:10.1182/blood.2024025406

McCulloch TR, Rossi GR, Alim L, Lam PY, Wong JKM, Coleborn E, Kumari S, Keane C, Kueh AJ, Herold MJ, Wilhelm C, Knolle PA, Kane L, Wells TJ, Souza-Fonseca-Guimaraes F. Dichotomous outcomes of TNFR1 and TNFR2 signaling in NK cell-mediated immune responses during inflammation. Nature Communications. 2024;15(1):10.1038/s41467-024-54232-y

Cheung BB, Mittra R, Murray J, Wang Q, Seneviratne JA, Raipuria M, Wong IPL, Restuccia D, Gifford A, Salib A, Sutton S, Huang L, Ferdowsi PV, Tsang J, Sekyere E, Mayoh C, Luo L, Brown DL, Stow JL, Zhu S, Young RJ, Solomon BJ, Chappaz S, Kile B, Kueh A, Herold MJ, Hilton DJ, Liu T, Norris MD, Haber M, Carter DR, Parker MW, Marshall GM. Golgi-localized Ring Finger Protein 121 is necessary for MYCN-driven neuroblastoma tumorigenesis. Communications Biology. 2024;7(1):10.1038/s42003-024-06899-8

Lieschke E, Thomas AF, Kueh A, Atkin-Smith GK, Baldoni PL, La Marca JE, Young S, Huang AS, Ross AM, Whelan L, Kaloni D, Tai L, Smyth GK, Herold MJ, Hawkins ED, Strasser A, Kelly GL. Mouse models to investigate in situ cell fate decisions induced by p53. The EMBO Journal. 2024;43(19):10.1038/s44318-024-00189-z

Swiderski K, Naim T, Trieu J, Chee A, Herold MJ, Kueh AJ, Goodman CA, Gregorevic P, Lynch GS. Dystrophin S3059 phosphorylation partially attenuates denervation atrophy in mouse tibialis anterior muscles. Physiological Reports. 2024;12(13):10.14814/phy2.16145

Behrens K, Kauppi M, Viney EM, Kueh AJ, Hyland CD, Willson TA, Salleh L, de Graaf CA, Babon JJ, Herold MJ, Nicola NA, Alexander WS. Differential in vivo roles of Mpl cytoplasmic tyrosine residues in murine hematopoiesis and myeloproliferative disease. Leukemia. 2024;38(6):10.1038/s41375-024-02219-5

Audiger C, Laâbi Y, Nie J, Gibson L, Wilson-Annan J, Brook-Carter P, Kueh A, Harris AW, Naik S, Nutt SL, Strasser A, Adams JM, Bouillet P, Chopin M. Mis-expression of GATA6 re-programs cell fate during early hematopoiesis. Cell Reports. 2024;43(5):10.1016/j.celrep.2024.114159

Yew MJ, Heywood SE, Ng J, West OM, Pal M, Kueh A, Lancaster GI, Myers S, Yang C, Liu Y, Reibe S, Mellett NA, Meikle PJ, Febbraio MA, Greening DW, Drew BG, Henstridge DC. ACAD10 is not required for metformin’s metabolic actions or for maintenance of whole‐body metabolism in C57BL/6J mice. Diabetes Obesity and Metabolism. 2024;26(5):10.1111/dom.15484

Ng SS, De Labastida Rivera F, Yan J, Corvino D, Das I, Zhang P, Kuns R, Chauhan SB, Hou J, Li X-Y, Frame TCM, McEnroe BA, Moore E, Na J, Engel JA, Soon MSF, Singh B, Kueh AJ, Herold MJ, Montes de Oca M, Singh SS, Bunn PT, Aguilera AR, Casey M, Braun M, Ghazanfari N, Wani S, Wang Y, Amante FH, Edwards CL, Haque A, Dougall WC, Singh OP, Baxter AG, Teng MWL, Loukas A, Daly NL, Cloonan N, Degli-Esposti MA, Uzonna J, Heath WR, Bald T, Tey S-K, Nakamura K, Hill GR, Kumar R, Sundar S, Smyth MJ, Engwerda CR. Author Correction: The NK cell granule protein NKG7 regulates cytotoxic granule exocytosis and inflammation. Nature Immunology. 2024;25(4):10.1038/s41590-024-01770-8

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