There are many links between abnormal development and disease. For example, the molecular mechanisms underlying the rapid, but regulated, growth of cells during embryonic development are frequently deregulated in cancer. Our aim is to utilise this knowledge to identify potential new targets for therapy.
We are particularly interested in the packaging of genetic material (DNA) with proteins in the cell nucleus, which influences how cells use different genes. The packaging of DNA can also be disrupted in disease.
Diseases of interest include intellectual disability disorders, prenatal stroke, blood stem cell failure, muscular dystrophy and cancer.