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- Jointly targeting IGF-1R and IR in cancer
- Targeting necroptosis for the treatment of inflammatory diseases
- Soluble CD52 as a therapeutic for inflammatory disease
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- Associate Professor Aaron Jex
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- Dr Rhys Allan
- Dr Ruth Kluck
- Dr Samar Ojaimi
- Dr Samir Taoudi
- Dr Shalin Naik
- Dr Simon Chatfield
- Dr Stephen Wilcox
- Dr Tracy Putoczki
- Dr Wai-Hong Tham
- Dr Wei Shi
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- Education
- PhD
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- Student research projects
- A novel role for Mind Bomb-2 (MIB2) in cell death and inflammation
- A systems approach to tackle immune complexity
- Antigenic diversity of malaria parasites: towards more effective malaria vaccines
- Apoptotic caspases, cell death, infection, inflammation and cancer
- Biological sequence analysis and genomic variant discovery
- Cell biology of killer CAR-T cells: improving immunotherapy
- Cell death, homeostasis and senescence in the immune system
- Cell-specific gene expression in autistic and schizophrenic human brains
- Chemical probing to identify effectors of necroptotic cell death
- Choreography of cell death by necroptosis
- Combining imaging and mathematics to understand immunity and cancer
- Computational comparative genomics of the scabies mite
- Computational systems biology of Wnt/cell adhesion signalling in colon cancer
- Controlling apoptotic cell death in cancer
- Cross-talk between cell death and inflammatory signalling pathways
- Cytokine control of blood cell function in health and disease
- Death-eating: how cell death pathways regulate autophagy
- Deciphering mechanisms of thrombocytopenia (low platelet count) in blood cancers
- Defining the function of the interleukin-11 signalling complex
- Determining the geographic origin of pathogenic human mutations
- Determining the migration signals that lead to protective immune responses
- Determining the requirements for T cell memory
- Developing and testing new drugs to treat inflammatory diseases
- Developing intracellular antibodies to trigger apoptotic cell death
- Discovery and analysis of autoimmune regulators
- Drug targets and compounds that block growth of malaria parasites
- Dying to survive: mechanistic insights into human bowel cancer development
- Dynamic discovery of innate immunity through imaging and genomics
- Emerging role of pseudokinases in cancer
- Epigenetic targeting of plasmacytoid dendritic cells to treat lupus
- Finding non-standard causes of monogenic disorders
- Function of proteins involved in invasion of erythrocytes by malaria parasites
- Home renovations: understanding how Toxoplasma redecorates its host cell
- How TNF signalling pathways govern T cell development and homeostasis
- How do killer cells detach from target cells?
- Identification of RNA biomarkers in autism
- Identification of malaria parasite entry receptors
- Identification of the key regulators of plasma cell biology
- Identifying new epigenetic approaches to treat autoimmune disease
- Identifying the functional basis of recent selective sweeps in the malaria genome
- Immune evasion strategies of malaria parasites
- Immune mechanisms of vascular disease
- Investigating breast cancer development in BRCA1/2 mutation carriers
- Investigating mechanisms of cell death and survival using zebrafish
- Investigating mechanisms of innate immune activation
- Investigating the biology of lung cancer
- Let me in! How Toxoplasma invades human cells
- Long-read sequencing for transcriptome and epigenome analysis
- Mechanics of T cell receptor activation
- Mechanistic and functional drivers of cancer neochromosomes
- Membrane transport studies
- Molecular genetics of megakaryocytic leukaemia
- New therapeutics for metastatic colorectal and pancreatic cancers
- Next-generation mucolytics to treat lung diseases
- No sex please, we’re inhibited: searching for drugs to prevent malaria transmission
- Novel real-time, quantitative imaging approaches for studying malaria
- Probing the control of lineage fate and function in the blood forming system
- Protein export to hijack human cells during liver-stage malaria
- Quantitation of human T cell expansion in health and disease
- Reconstructing the immune response: from molecules to cells to systems
- Regulation of cytokine signalling
- Regulation of normal and cancerous intestinal stem cell dynamics by PHLDA1
- Role of cell death in blood vessel growth and regression
- Single cell RNA-seq for biomarker discovery and immune status assessment
- Statistical bioinformatic analyses of RNA-seq and ChIP-seq data
- Stopping the rogue immune cells that attack pancreatic islets in diabetes
- Structural and biochemical studies on Notch signal transduction
- Structural and functional analysis of malaria invasion
- Structural biology and drug discovery for Bcl-2 family proteins
- Structural studies of human voltage dependent anion channel 2
- Structural studies of invasion processes during malaria infection
- Structural studies of the Plasmodium and Toxoplasma tight-junction complex
- Structure and function of the enigmatic cell death protein Bok
- Structure function studies of the Pyrin inflammasome
- Student research opportunity
- Systems approach to understand adipose inflammation and type 2 diabetes
- TNF-induced inflammation, inflammatory bowel disease and colon cancer
- Target identification of potent antimalarial agents
- The importance of glycosylation in malaria infection of the mosquito and human host
- The molecular basis of host cell traversal by malaria parasites
- The quantitative impact of immune checkpoints on T cell proliferation
- Towards a molecular description of plasma cell diversity
- Tracking the spread of malaria in the Asia Pacific region
- Transmembrane control of type I cytokine receptor activation
- Tumour heterogeneity and evolution
- Uncovering the roles of long non-coding RNAs in human bowel cancer
- Understanding mitochondrial pore formation during apoptotic cell death
- Understanding the ATPase domain of the epigenetic regulator, Smchd1
- Understanding the development of humoral immunity to malaria
- Understanding the mechanisms of drug resistance in acute myeloid leukaemia
- Unraveling excystation in Giardia lablia
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Putoczki-Publications
Researcher:
Selected publications
- Poh AR, O'Donoghue RJ, Ernst M, Putoczki TL. Mouse models for gastric cancer: Matching models to biological questions. J Gastroenterol Hepatol. 2016 Jan 25. doi: 10.1111/jgh.13297. [Epub ahead of print] Review. PMID: 26809278
- Rankin LC, Girard-Madoux MJ, Seillet C, Mielke LA, Kerdiles Y, Fenis A, Wieduwild E, Putoczki T, Mondot S, Lantz O, Demon D, Papenfuss AT, Smyth GK, Lamkanfi M, Carotta S, Renauld JC, Shi W, Carpentier S, Soos T, Arendt C, Ugolini S, Huntington ND, Belz GT, Vivier E. Complementarity and redundancy of IL-22-producing innate lymphoid cells. Nat Immunol. 2016 Feb;17(2):179-86. doi: 10.1038/ni.3332. Epub 2015 Nov 30. PMID: 26595889
- Mielke L, Preaudet A, Belz G, Putoczki T. Confocal laser endomicroscopy to monitor the colonic mucosa of mice. J Immunol Methods. 2015 Jun;421:81-8. doi: 10.1016/j.jim.2015.04.012. Epub 2015 May 8. PMID: 25960174
- Ernst M, Preaudet A, Putoczki T. Non-invasive assessment of the efficacy of new therapeutics for intestinal pathologies using serial endoscopic imaging of live mice. J Vis Exp. 2015 Mar 10;(97). doi: 10.3791/52383. PMID: 25867916
- Ernst M, Putoczki TL. Molecular Pathways: IL11 as a Tumor-Promoting Cytokine-Translational Implications for Cancers. Clinical cancer research : an official journal of the American Association for Cancer Research. 2014 Jul 29. PMID: 25074610. Epub 2014/07/31. Eng.
- Ernst M, Thiem S, Nguyen PM, Eissmann M, Putoczki TL. Epithelial gp130/Stat3 functions: an intestinal signaling node in health and disease. Seminars in immunology. 2014 Feb;26(1):29-37. PMID: 24434062. Epub 2014/01/18. eng.
- Stuart E, Buchert M, Putoczki T, Thiem S, Farid R, Elzer J, Huszar D, Waring PM, Phesse TJ, Ernst M. Therapeutic inhibition of Jak activity inhibits progression of gastrointestinal tumors in mice. Molecular cancer therapeutics. 2014 Feb;13(2):468-74. PMID: 24398427. Epub 2014/01/09. eng.
- Putoczki TL, Thiem S, Loving A, Busuttil RA, Wilson NJ, Ziegler PK, Nguyen PM, Preaudet A, Farid R, Edwards KM, Boglev Y, Luwor RB, Jarnicki A, Horst D, Boussioutas A, Heath JK, Sieber OM, Pleines I, Kile BT, Nash A, Greten FR, McKenzie BS, Ernst M. Interleukin-11 is the dominant IL-6 family cytokine during gastrointestinal tumorigenesis and can be targeted therapeutically. Cancer cell. 2013 Aug 12;24(2):257-71. PMID: 23948300. Epub 2013/08/21. eng.
- Bollrath J, Phesse TJ, von Burstin VA, Putoczki T, Bennecke M, Bateman T, Nebelsiek T, Lundgren-May T, Canli O, Schwitalla S, Matthews V, Schmid RM, Kirchner T, Arkan MC, Ernst M, Greten FR. gp130-mediated Stat3 activation in enterocytes regulates cell survival and cell-cycle progression during colitis-associated tumorigenesis. Cancer cell. 2009 Feb 3;15(2):91-102. PMID: 19185844. Epub 2009/02/03. eng.
- Putoczki T, Ernst M. More than a sidekick: the IL-6 family cytokine IL-11 links inflammation to cancer. Journal of leukocyte biology. 2010 Dec;88(6):1109-17. PMID: 20610798. Epub 2010/07/09. eng.
Super Content:
Dr Tracy Putoczki presents on her research into inflammation associated cancers (gp130 signalling)
