Selected publications

1. Alcon P, Shakeel S, Chen ZA, Rappsilber J, Patel KJ, Passmore LA. FANCD2-FANCI is a clamp stabilized on DNA by monoubiquitination of FANCD2 during DNA repair. Nat Struct Mol Biol. 2020. 27, 240-248 PMID: 32066963 
2. Farrell DP, Anishchenko I, Shakeel S, Lauko A, Passmore LA, Baker D, DiMaio F. Deep learning enables the atomic structure determination of the Fanconi Anemia core complex from cryoEM. IUCrJ. 2020. 7, 881-892 PMID: 32939280 
3. Laurinmaki P, Shakeel S, Ekstrom JO, Mohammadi P, Hultmark D, Butcher SJ. Structure of Nora virus at 2.7 A resolution and implications for receptor binding, capsid stability and taxonomy. Sci Rep. 2020. 10, 19675 PMID: 33184473 
4. Shakeel S, Rajendra E, Alcon P, O'Reilly F, Chorev DS, Maslen S, Degliesposti G, Russo CJ, He S, Hill CH et al. Structure of the Fanconi anaemia monoubiquitin ligase complex. Nature. 2019. 575, 234-237 PMID: 31666700 
5. Shakeel S, Dykeman EC, White SJ, Ora A, Cockburn JJB, Butcher SJ, Stockley PG, Twarock R. Genomic RNA folding mediates assembly of human parechovirus. Nat Comm. 2017. 8, PMID: 28232749
6. Shakeel S, Westerhuis BM, Domanska A, Koning RI, Matadeen R, Koster AJ, Bakker AQ, Beaumont T, Wolthers KC, Butcher SJ. Multiple capsid-stabilizing interactions revealed in a high-resolution structure of an emerging picornavirus causing neonatal sepsis. Nat Comm. 2016. 7, 11387 PMID: 27435188 
7. Shakeel S, Westerhuis BM, Ora A, Koen G, Bakker AQ, Claassen Y, Wagner K, Beaumont T, Wolthers KC, Butcher SJ. Structural basis of human parechovirus neutralization by human monoclonal antibodies. J Virol. 2015. 89, 9571-9580 PMID: 26157123 
8. Pandurangan AP, Shakeel S, Butcher S, Topf M. Combined approaches to flexible fitting and assessment in virus capsids undergoing conformational change. J Struct Biol. 2014. 185, 427-439 PMID: 24333899
9. Shakeel S, Seitsonen JJ, Kajander T, Laurinmaki P, Hyypiä T, Susi P, Butcher SJ. Structural and functional analysis of coxsackievirus A9 integrin alphavbeta6 binding and uncoating. J Virol. 2013. 87, 3943-3951 PMID: 23365426 
10. Seitsonen JJ, Shakeel S, Susi P, Pandurangan AP, Sinkovits RS, Hyvonen H, Laurinmaki P, Yla-Pelto J, Topf M, Hyypiä T et al. Structural analysis of coxsackievirus A7 reveals conformational changes associated with uncoating. J Virol. 2012. 86, 7207-7215 PMID: 22514349 

Further publications