Possible link between rotavirus vaccine and decline in type 1 diabetes
22 January 2019
A drop in the number of young children diagnosed with type 1 diabetes could be associated with the introduction of routine rotavirus vaccination of Australian infants, according to a new study by Melbourne researchers.
In type 1 diabetes, the insulin-producing cells found in ‘islets’ in the pancreas (shown in purple) are destroyed by a misdirected immune response.
The researchers investigated the number of Australian children diagnosed with type 1 diabetes from 2000 to 2015 and found that type 1 diabetes diagnoses in children aged 0-4 years declined from 2007 – the year that rotavirus vaccine was introduced as a routine infant vaccination.
This is the first time the rate of type 1 diabetes in young children in Australia has fallen since the 1980s. While not conclusively linking the rotavirus vaccine with protection against type 1 diabetes, the discovery builds on earlier research suggesting natural rotavirus infection may be a risk factor for type 1 diabetes.
The number of children diagnosed with type 1 diabetes has steadily increased in Australia since the 1980s, but the reasons for this have been poorly understood.
Melbourne researchers identified the first fall in type 1 diabetes in young Australian children born after 2007.
The fall in type 1 diabetes incidence in young children coincided with the introduction of the rotavirus vaccine as a routine infant vaccination. This follows on from earlier research implicating rotavirus infection in children as a risk factor for developing type 1 diabetes.
Decline in type 1 diabetes
Since the 1980s, the incidence of type 1 diabetes has steadily increased in Australia and worldwide, but the reasons for this increase are poorly understood. Type 1 diabetes is a serious, lifelong autoimmune condition, in which the body’s immune system destroys cells in the pancreas that produce insulin, a hormone that controls the level of glucose in the blood.
Dr Kirsten Perrett from the Murdoch Children’s Research Institute has led a study revealing the rate of type 1 diabetes has fallen for the first time in young children in Australia.
By investigating the number of Australian children diagnosed with type 1 diabetes each year since 2000, the research team observed that after 2007 the rate of type 1 diabetes decreased in children aged 0-4 years, said study lead Dr Kirsten Perrett from the Murdoch Children’s Research Institute.
“The significant decrease in type 1 diabetes that we detected in young children after 2007 was not seen in older children aged 5-14. This suggests the young children could have been exposed to a protective factor that didn’t impact older children,” Dr Perrett said.
“We observed the decline in the rate of type 1 diabetes in children born after 2007 coincided with the introduction of the oral rotavirus vaccine onto the Australian National Immunisation Program in 2007.”
The rotavirus vaccine is routinely given to Australian infants aged two and four months to protect them against a severe, potentially life-threatening form of diarrhoea.
Exploring the connection
Professor Len Harrison from the Walter and Eliza Hall Institute, who is the study senior author, said the discovery followed on from earlier research implicating rotavirus infection in the development of type 1 diabetes.
Walter and Eliza Hall Institute Professor Len Harrison is a senior author on research suggesting a possible link between rotavirus and type 1 diabetes.
“Twenty years ago our team revealed an association between the appearance of immune markers of type 1 diabetes in children and rotavirus infection. Subsequent studies in laboratory models suggested rotavirus infection of pancreatic cells can trigger an immune attack against the insulin-producing cells – similar to what occurs in type 1 diabetes,” he said.
“While not conclusive, our latest study suggests that preventing rotavirus infection in Australian infants by vaccination may also reduce their risk of type 1 diabetes. We will be continuing this research to look more closely at the correlation, by comparing the health records of young children with or without type 1 diabetes.
“At this stage we don’t yet know whether the reduction in type 1 diabetes is a permanent effect or transient, and it may only be relevant to Australian children,” Professor Harrison said.
The research was supported by the National Health and Medical Research Council, a Melbourne Children’s Clinician-Scientist Fellowship, a Murdoch Children’s Research Institute grant, the Colin North Diabetes Fund and the Victorian Government.
Dr Perrett and Professor Harrison hold honorary positions at the University of Melbourne.
