The WEHI Advanced Genomics Facility

The WEHI Advanced Genomics Platforms Team operates a suite of sequencing and other genomics instruments, including Illumina MiSeq and NextSeq 500, Oxford Nanopore PromethION, MGI and PacBio Sequel, alongside 10x Genomics Chromium and MissionBio Tapestri.

We provide sequencing as a service to internal users, for Cellular Genomics projects, and on a limited basis to external researchers.

Please contact Dr Stephen Wilcox for more information.

The Cellular Genomics Projects Team, formerly SCORE, provides single-cell and spatial omics, high-throughput transcriptomics and other advanced genomics capacity to WEHI researchers, institutional partners and selected collaborators around the Melbourne Biomedical Precinct.

We operate an integrated platform where biologists, technologists and computational biologists collaborate to apply the latest approaches to basic and clinical research questions, often with the assistance of our R&D team. By bringing a full suite of technologies together in one place we lower the financial and logistical barriers to entry into advanced genomics.

Members of the WEHI Genomics Lab, which hosts the WEHI Advanced Genomics Facility, have a substantial track record of adapting and implementing genomics methodologies and sequencing workflows, both for cellular genomics and in other areas such as pathogen genomics. The R&D Team, alongside the Projects and Platforms Teams, is responsible for the evaluation and introduction of new genomics instrumentation.

Current areas of R&D priority include:

• sequencing technologies
• spatial methods
• high-throughput screens
• epigenomics
• cohorts
• precision medicine

The Genomics R&D Team supports a proportion of Cellular Genomics projects that require methods development or validation on a collaborative basis.

We also undertake collaborative proof-of-concept studies in preparation for introducing new technologies and applications, and to support applications for scientific project funding.

Please contact Dr Rory Bowden to discuss collaborative opportunities.

Researchers are invited to access the Olink Proteomics Platform at WEHI. We are proud to be the first laboratory in Australia to run Olink for service and collaborative research projects.

Olink is a next-generation affinity proteomics technology for quantification of thousands of low concentration proteins in collections of clinical or experimental samples, using only a few microlitres per sample.

Olink Explore and Explore-HT platforms are now available at WEHI enabling high-throughput biomarker screening, while we have offered analysis using the Olink Target platform since 2022.

We offer Olink for researchers under either a collaborative cost-recovery model, or a fee-for-service model.

Please contact us at olink@wehi.edu.au to discuss your project aims and requirements.