WEHI Special Immunology Seminar hosted by Dr Melinda Hardy
 

Associate Professor Stuart Mannering

Head – Human T-cell Laboratory, Immunology and Diabetes Unit, St Vincent’s Institute of Medical Research

Dissecting the immune pathogenesis of autoimmune diabetes in humans

Davis Auditorium

Join via TEAMS

Including Q&A session

A/Prof Stuart Mannering completed his PhD, in 1998, on human Dendritic cells with Prof Derek Hart. After postdocs at The University of Melbourne and the Walter and Eliza Hall Institute he established his group at St. Vincent’s Institute of Medical Research in 2008. His group’s research has two related goals. One is to understand ‘how and why’ human T cells cause type 1 diabetes. The second is to use this knowledge to develop tools and methods for measuring and modulating beta-cell antigen specific T-cell responses in people with T1D.

Eventually this work will contribute to the development of effective antigen-specific therapies to prevent, or eventually cure, T1D. He developed the CFSE-based proliferation assay, identified the first neoepitope implicated in T1D, was the first to isolate and analyze viable human-islet infiltrating T cells and showed the C-peptide is a major autoantigen in human T1D.  The group’s work is currently supported by grants from: JDRF, Helmsley Charitable Trust and the MRFF.

All welcome!