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- A complete cure for HBV
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- Novel malaria vaccine
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- A new regulator of stemness to create dendritic cell factories for immunotherapy
- Advanced methods for genomic rearrangement detection
- Control of cytokine signaling by SOCS1
- Defining the protein modifications associated with respiratory disease
- Delineating the pathways driving cancer development and therapy resistance
- Developing a new drug that targets plasmacytoid dendritic cells for the treatment of lupus
- Development and mechanism of action of novel antimalarials
- Development of a novel particle-based malaria vaccine
- Development of tau-specific therapeutic and diagnostic antibodies
- Discovering novel therapies for major human pathogens
- Dissecting host cell invasion by the diarrhoeal pathogen Cryptosporidium
- Epigenetic biomarkers of tuberculosis infection
- Essential role of glycobiology in malaria parasites
- Evolution of haematopoiesis in vertebrates
- Human lung protective immunity to tuberculosis
- Identifying novel treatment options for ovarian carcinosarcoma
- Interaction with Toxoplasma parasites and the brain
- Interactions between tumour cells and their microenvironment in non-small cell lung cancer
- Investigating the role of mutant p53 in cancer
- Microbiome strain-level analysis using long read sequencing
- Minimising rheumatic adverse events of checkpoint inhibitor cancer therapy
- Modelling spatial and demographic heterogeneity of malaria transmission risk
- Naturally acquired immune response to malaria parasites
- Predicting the effect of non-coding structural variants in cancer
- Structural basis of catenin-independent Wnt signalling
- Structure and biology of proteins essential for Toxoplasma parasite invasion
- T lymphocytes: how memories are made
- TICKER: A cell history recorder for longitudinal patient monitoring
- Targeting host pathways to develop new broad-spectrum antiviral drugs
- Targeting post-translational modifications to disrupting the function of secreted proteins
- Targeting the epigenome to rewire pro-allergic T cells
- Targeting the immune microenvironment to treat KRAS-mutant adenocarcinoma
- The E3 ubiquitin ligase Parkin and mitophagy in Parkinson’s disease
- The molecular controls on dendritic cell development
- Understanding malaria infection dynamics
- Understanding the genetics of neutrophil maturation
- Understanding the neuroimmune regulation of innate immunity
- Understanding the proteins that regulate programmed cell death at the molecular level
- Using cutting-edge single cell tools to understand the origins of cancer
- When healthy cells turn bad: how immune responses can transition to lymphoma
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Start-up companies

We have established several companies to facilitate research translation and to promote collaboration. These are some examples of start-up companies which have been created with intellectual property developed at the Institute.
IonOpticks
IonOpticks develops and manufactures an innovative nano capillary chromatography column with integrated emitter tip used in the proteomics research field.
Spun out of the Walter and Eliza Hall Institute, it successfully launched its nano capillary chromatography columns to the global proteomics research market in 2017. Their columns were developed for analytical applications used in medical research such as cancer, Parkinson’s disease and other age-related diseases. The product provides a unique ability to enhance the sensitivity of biological sample analysis, enabling scientists to achieve a 25 per cent improvement in performance compared to other commercially available solutions.

Anaxis Pharma Pty Ltd
Anaxis Pharma Pty Ltd is an Australian Biotech company developing novel inhibitors / modulators of cell death, specifically necroptosis, an inflammatory form of programmed cell death.
As an innovative joint venture between Synthesis Research and the Walter and Eliza Hall Institute of Medical Research, we leverage the extensive expertise and capabilities of the Institute, with the medicinal chemistry experience available to SYNthesis Research.
Genera Biosystems Limited
An Australian publicly listed company (ASX: GBI) that develops and commercialises multiplexed molecular diagnostic tests, based upon its proprietary AmpaSandTM bead-based technology.
Genera’s first product on sale is PapTypeTM, a highly competitive molecular diagnostic test for the simultaneous detection and genotyping of the 14 high-risk types of human papillomavirus (HPV) and RTIplex, a multiplexed test for 15 pathogens of the upper respiratory tract. The company has a number of other products in its development pipeline.
MuriGen Therapeutics Limited
An Australian-based drug discovery and development company building a portfolio of novel drugs for unmet medical needs across a number of therapeutic areas including cancer, arthritis, thrombocytopenia and inflammation.
By leveraging its proprietary drug discovery platform, MuriGen Therapeutics is working towards the validation of novel drug targets that have the potential to provide significant benefits for researchers, health care practitioners, and patients.
Catalyst Therapeutics
Catalyst Therapeutics Pty Ltd, founded in 2012, is a joint venture between the Walter and Eliza Hall Institute of Medical Research and SYNthesis Research Pty Ltd. The company facilitates and accelerates the commercialisation of small molecule drug discoveries originating at the Institute.