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Areas
Diseases
  • Autoinflammatory disease
  • Neurodevelopmental disorder
Technologies
  • Molecular biology
  • Mouse genetics
  • Transcriptomics
  • CRISPR

Publications

Selected publications from Dr Jacki Heraud-Farlow

Varada R, Leuchtenberger AF, Vesely C, Kaczmarek B, Khosravi HM, Mandl TC, Milanovic K, Tamizkar KH, Rajendra V, Senoner H, Steinbichl L, Borojevic M, Sombke A, Schmidt K, Eckhard M, Hofacker IL, Walkley C, Heraud-Farlow JE, Picardi E, Bernecky C, Jantsch MF. Distinguishing self from non-self RNA by editing-specific inosine patterns. Nucleic Acids Research. 2026;54(16):10.1093/nar/gkag845

Liu L, Glaser A, Isiaku AI, Fairfax K, Casolari DA, Ristovski A, Murphy V, van Twest S, Henrikus SS, Heraud-Farlow J, Granger E, Novakovic S, O’Byrne SFM, Tsui V, Conyers R, Gonda TJ, Crismani W, D’Andrea RJ, Heierhorst J, Deans AJ. Fancl-mutant mice reveal central role of monoubiquitination in Fanconi anemia and a model for therapeutic gene editing. Blood Advances. 2026;10(3):10.1182/bloodadvances.2025017217

Heraud-Farlow JE, Taylor SR, Chalk AM, Escudero A, Hu S-B, Goradia A, Sun T, Li Q, Nikolic I, Li JB, Fidalgo M, Guallar D, Simpson KJ, Walkley CR. GGNBP2 regulates MDA5 sensing triggered by self double-stranded RNA following loss of ADAR1 editing. Science Immunology. 2024;9(101):10.1126/sciimmunol.adk0412

Liang Z, Walkley CR, Heraud-Farlow JE. A-to-I RNA editing and hematopoiesis. Experimental Hematology. 2024;139:10.1016/j.exphem.2024.104621

Walkley C, Heraud-Farlow J, Stewart M, Smeets M, Izon D, Taylor S, Liang Z, Chalk A, Goradia A, Hu S-B, Li JB, Purton L. 3192 – ADAR1P150 PROTEIN, INDEPENDENT OF ITS A-TO-I RNA EDITING ACTIVITY, REGULATES PERIPHERAL T CELL HOMEOSTASIS AND HSC REPOPULATING CAPACITY. Experimental Hematology. 2024;137:10.1016/j.exphem.2024.104512

Hu S-B, Heraud-Farlow J, Sun T, Liang Z, Goradia A, Taylor S, Walkley CR, Li JB. ADAR1p150 prevents MDA5 and PKR activation via distinct mechanisms to avert fatal autoinflammation. Molecular Cell. 2023;83(21):10.1016/j.molcel.2023.09.018

Liang Z, Goradia A, Walkley CR, Heraud-Farlow JE. Generation of a new Adar1p150−/− mouse demonstrates isoform-specific roles in embryonic development and adult homeostasis. RNA. 2023;29(9):10.1261/rna.079509.122

Liang Z, Chalk AM, Taylor S, Goradia A, Heraud‐Farlow JE, Walkley CR. The phenotype of the most common human ADAR1p150 Zα mutation P193A in mice is partially penetrant. EMBO Reports. 2023;24(5):10.15252/embr.202255835

Ruiz SM, Chalk AM, Goradia A, Heraud-Farlow J, Walkley CR. Over-expression of ADAR1 in mice does not initiate or accelerate cancer formation in vivo. NAR Cancer. 2023;5(2):10.1093/narcan/zcad023

Walkley C, Ruiz SM, Chalk A, Goradia A, Heraud-Farlow J. 3210 – OVER-EXPRESSION OF ADAR1 IN MICE DOES NOT INITIATE OR ACCELERATE CANCER FORMATION IN VIVO.Experimental Hematology. 2023;124:10.1016/j.exphem.2023.06.317

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