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About

I am interested in the field of gene-editing and the generation of mouse models. Our group has used CRISPR gene-editing technology to generate highly complex mouse models and we are currently investigating the use of various CRISPR enzymes to increase the efficiency and speed of generating these models.

Publications

Selected publications from Dr Andrew Kueh

Keating N, Doggett K, Bidgood GM, Meza Guzman LG, Dagley LF, Li K, Williams BE, Gabrielyan A, Alvarado C, Broomfield BJ, Duckworth BC, Hockings C, Yousef J, Leong E, Morris R, Kueh A, Garnham AL, Giner G, Casanova J-L, Boisson-Dupuis S, Babon JJ, Linossi EM, Tate MD, Groom JR, Nicholson SE. ARAP2 regulates responses to interferon-gamma by restricting SOCS1. Cell Reports. 2025;44(12):10.1016/j.celrep.2025.116667

Santavanond JP, Atkin-Smith GK, Lozano-González I, Roncero-Carol J, Jiang L, Hodge AL, Ozkocak DC, Zhao K, Gray DHD, Herold MJ, Kueh AJ, Ryan GF, Tixeira R, Olson MF, Hulett MD, Baxter AA, Poon IKH, Hoijman E. Resident phagocytes promote non–cell-autonomous fragmentation of apoptotic cells. Science Advances. 2025;11(51):10.1126/sciadv.adz5264

La Marca J, Diepstraten S, Jin W, Deng Y, Potts M, Heidersbach A, Lelliott E, Koenig C, Brown F, Chang C, Dorighi K, Kueh A, Tai L, Whelan L, Kelly G, Fortin J-P, Haley B, Herold M. 3107 – ADVANCED CRISPR KNOCKOUT AND ACTIVATION MOUSE MODELS AS TOOLS FOR INVESTIGATING HEMATOLOGY AND HEMATOLOGICAL MALIGNANCIES. Experimental Hematology. 2025;151:10.1016/j.exphem.2025.105048

Krishan S, Koach J, Lim T, Yeo K, Cheong F, Luo J-S, Massudi H, Gao X, Heangsarath S, Kueh AJ, Herold MJ, Cheung BB, Marshall GM. PA2G4 Functions as a Cofactor for MYC Family Oncoproteins in MYC-Driven Malignancies. Cells. 2025;14(18):10.3390/cells14181422

Brinkmann K, McArthur K, Malelang S, Gibson L, Tee A, Elahee Doomun SN, Rowe CL, Arandjelovic P, Marchingo JM, D’Silva D, Bachem A, Monard S, Whelan LG, Dewson G, Putoczki TL, Bouillet P, Fu NY, Brown KK, Kueh AJ, Wimmer VC, Herold MJ, Thomas T, Voss AK, Strasser A. Relative importance of the anti-apoptotic versus apoptosis-unrelated functions of MCL-1 in vivo. Science. 2025;389(6764):10.1126/science.adw1836

Yang J, Guo F, San Chin H, Bin Chen G, Zhang Z, Williams L, Kueh AJ, Chow PKH, Herold MJ, Fu NY. Rapid and Robust Generation of Homozygous Fluorescent Reporter Knock-In Cell Pools by CRISPR-Cas9. Cells. 2025;14(15):10.3390/cells14151165

Shojaee F, Azadian E, Wong MX, Ma X, Rickard J, Pang J, Hall C, Kueh AJ, Masters SL, Rioja I, Prinjha RK, Doerflinger M, Lawlor KE, Rashidi M, Vince JE. NLRP3 inflammasome–driven hemophagocytic lymphohistiocytosis occurs independent of IL-1β and IL-18 and is targetable by BET inhibitors. Science Advances. 2025;11(28):10.1126/sciadv.adv0079

Weber TS, Biben C, Miles DC, Glaser SP, Tomei S, Lin C-Y, Kueh A, Pal M, Zhang S, Tam PPL, Taoudi S, Naik SH. LoxCode in vivo barcoding reveals epiblast clonal fate bias to fetal organs. Cell. 2025;188(14):10.1016/j.cell.2025.04.026

Lawrence EM, Cooray A, Kueh AJ, Pal M, Tai L, Garnham AL, Li-Wai-Suen CSN, Vanyai H, Gouil Q, Lancaster J, Callegari S, Whelan L, Lieschke E, Thomas A, Strasser A, Liao Y, Shi W, Wei AH, Herold MJ. Transcriptomic changes including p53 dysregulation prime DNMT3A mutant cells for transformation. EMBO Reports. 2025;26(11):10.1038/s44319-025-00450-4

Arkell RM, Wolvetang EJ, Gulati T, Hennessy JE, Hill AP, Jardé T, Kueh AJ, Thomas PQ, Winteringham LN, Dobbie MS. Complementarity and integration of animal and in vitro non-animal pre-clinical model systems– an Australian perspective. Mammalian Genome. 2025;36(2):10.1007/s00335-025-10132-0

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