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About

I’m a bioinformatician with more than 9 years experience in the field. I have extensive experience in the analysis of all types of ‘omics data, and in the development of analysis pipelines for current and emerging technologies. I also have considerable experience in biostatistical analysis and experimental design.

Publications

Selected publications from Dr Alex Garnham

Xiong L, Diwakarla S, Chatzis R, Artaiz O, Macowan M, Zhang S, Garnham A, Morgan PK, Mellett NA, Meikle PJ, Lancaster GI, Marsland BJ, Nutt SL, Seillet C. Acute exposure to high-fat diet impairs ILC3 functions and gut homeostasis. Immunity. 2025;58(5):10.1016/j.immuni.2025.03.017

Lawrence EM, Cooray A, Kueh AJ, Pal M, Tai L, Garnham AL, Li-Wai-Suen CSN, Vanyai H, Gouil Q, Lancaster J, Callegari S, Whelan L, Lieschke E, Thomas A, Strasser A, Liao Y, Shi W, Wei AH, Herold MJ. Transcriptomic changes including p53 dysregulation prime DNMT3A mutant cells for transformation. EMBO Reports. 2025;:10.1038/s44319-025-00450-4

Bergamasco MI, Ogier JM, Garnham AL, Whitehead L, Rogers K, Smyth GK, Burt RA, Voss AK, Thomas T. Loss of KAT6B causes premature ossification and promotes osteoblast differentiation during development. Developmental Biology. 2025;520:10.1016/j.ydbio.2025.01.012

Bergamasco MI, Ozturk E, Casillas-Espinosa PM, Garnham AL, Abeysekera W, Wimmer VC, Rajasekhar P, Vanyai HK, Whitehead L, Blewitt ME, Rogers K, Vogel AP, Hannan AJ, Smyth GK, Jones NC, Thomas T, Voss AK. KAT6B overexpression in mice causes aggression, anxiety, and epilepsy. iScience. 2025;28(3):10.1016/j.isci.2025.111953

Bergamasco MI, Yang Y, Garnham AL, Sheikh BN, Smyth GK, Voss AK, Thomas T. KAT6B overexpression rescues embryonic lethality in homozygous null KAT6A mice restoring vitality and normal lifespan. Nature Communications. 2025;16(1):10.1038/s41467-025-57155-4

Bergamasco MI, Abeysekera W, Garnham AL, Hu Y, Li-Wai-Suen CS, Sheikh BN, Smyth GK, Thomas T, Voss AK. KAT6B is required for histone 3 lysine 9 acetylation and SOX gene expression in the developing brain. Life Science Alliance. 2025;8(2):10.26508/lsa.202402969

McRae HM, Leong MPY, Bergamasco MI, Garnham AL, Hu Y, Corbett MA, Whitehead L, El-Saafin F, Sheikh BN, Wilcox S, Hannan AJ, Gécz J, Smyth GK, Thomas T, Voss AK. Loss of PHF6 causes spontaneous seizures, enlarged brain ventricles and altered transcription in the cortex of a mouse model of the Börjeson–Forssman–Lehmann intellectual disability syndrome. PLOS Genetics. 2024;20(10):10.1371/journal.pgen.1011428

Stonehouse OJ, Biben C, Weber TS, Garnham A, Fennell KA, Farley A, Terreaux AF, Alexander WS, Dawson MA, Naik SH, Taoudi S. Clonal analysis of fetal hematopoietic stem/progenitor cells reveals how post-transplantation capabilities are distributed. Stem Cell Reports. 2024;19(8):10.1016/j.stemcr.2024.07.003

Bergamasco MI, Ranathunga N, Abeysekera W, Li-Wai-Suen CSN, Garnham AL, Willis SN, McRae HM, Yang Y, D’Amico A, Di Rago L, Wilcox S, Nutt SL, Alexander WS, Smyth GK, Voss AK, Thomas T. The histone acetyltransferase KAT6B is required for hematopoietic stem cell development and function. Stem Cell Reports. 2024;19(4):10.1016/j.stemcr.2024.02.005

Bergamasco MI, Vanyai HK, Garnham AL, Geoghegan ND, Vogel AP, Eccles S, Rogers KL, Smyth GK, Blewitt ME, Hannan AJ, Thomas T, Voss AK. Increasing histone acetylation improves sociability and restores learning and memory in KAT6B-haploinsufficient mice. Journal of Clinical Investigation. 2024;134(7):10.1172/jci167672

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