Dendritic cells (DCs) play a crucial role in safeguarding our body against infections and cancer. They diligently patrol our system, identifying the presence of pathogens or cancerous cells. Once detected, they activate T cells, enabling the elimination of these threats. However, various types of DCs exist, each possessing distinct functional properties that impact the overall immune response.
Acknowledging the significance of DCs in controlling infections and tumor growth and their diversity, our research team aims to better understand, at the single cell level,
- the development of these cells from stem cells and
- how they acquire specific functions, both in healthy conditions and during perturbations (inflammation or cancer).
This project will lead to not only a better comprehension of our immune response but also generate novel approaches to harness the power of DCs in future cell therapies.
Depending on their interest and the scientific question, the student will develop skills in cell culture, flow cytometry, genetic manipulation technic (CRISPR), lineage-tracing and single-cell technologies.