Exploring the multi-omics of gene regulation

• PhD

Complex life depends on multiple layers and dimensions of gene regulation. It is not sufficient for genes to be simply on or off. They require highly dynamic, responsive, and nuanced levels of expression.

Our lab, including previous students, has spent many years revealing this multi-dimensional complexity by combining cellular and molecular tools with various next-generation sequencing based technologies (RNA-Sequencing, ATAC-Sequencing, in situ HiC, capture HiC, Pore-C, among others) and imaging.

Current projects focus on optimisation and analysis of long read proximity ligation technologies (Pore-C), the impact of single nucleotide polymorphisms on transcription factor binding and genome architecture, among others.

These projects would be best suited to a student with a strong bioinformatic/computer science background or one with interest in developing these skills. Projects can be tailored to suit a student’s skill set.

The Allan Lab focuses on the molecular regulation of the immune system, in both health and disease. We have a long record of combining cutting-edge technologies (RNA-Seq, single cell RNA-Seq, ATAC-Seq, in situ HiC, capture HiC, Pore-C, chromosome paint, among others) with bioinformatics to make impactful discoveries.

We enjoy highly collaborative projects and have well established networks with scientists at WEHI, across Australia and around the world. This provides an excellent interdisciplinary training environment for students, as well as opportunities to build valuable networks.