Artificial intelligence guided design of novel Chimeric Antigen Receptor (CAR) T cell brain cancer targets

• Graduate Research Masters
• Honours

“Glioblastoma is an aggressive form of brain cancer with limited effective treatment options. Chimeric Antigen Receptor (CAR) T cell therapy, an emerging field involving the engineering of immune cells, holds great potential for the treatment of glioblastoma. A limitation arises in a lack of existing biologics targeting tumour specific markers.

This project will aim to design synthetic protein-based biologics with generative Artifical Intelligence (AI). This is an opportunity for students with an interest in synthetic and computational biology to develop their skills. A distinguishing feature of this project is that the most promising designs will undergo experimental validation within our laboratory. Additionally, students demonstrating exceptional motivation will have the opportunity to enhance their expertise through hands-on experience in experimental techniques.”

The Bowden Laboratory is interested in improving how we study genomes and their organisation and expression, focusing particularly on infection, the study of individual cells and ways to exploit DNA sequencing to develop new treatments for disease.

Our laboratory hosts the WEHI Genomics facility. We support WEHI in accessing all forms of genomics technology, through a comprehensive suite of advanced preparation platforms and sequencing technologies, and a dynamic R&D program that matches WEHI’s areas of scientific focus.