The WEHI Antibody Facility provides antibody services to academic researchers and commercial clients.
Established in 1991 the facility is staffed by an experienced and multidisciplinary team who work collaboratively with researchers, providing expert advice and versatility in experimental design. The team can develop monoclonal and polyclonal antibodies to novel targets, and adapt and refine protocols to suit researcher requirements.
Core services include:
An extensive repository of purified antibodies is available and can be conjugated to meet specific researcher requirements.
Nanobodies are laboratory-made antibody fragments from camelids or cartilaginous fish that consist of a single heavy chain variable domain. Nanobodies are of interest as both therapeutics and research tools due to their small size, high antigen-binding affinity and their increased stability across temperature and pH range.
To generate nanobodies, our researchers immunise alpacas with a target protein. Nanobody genes from isolated plasma cells of the immunised alpaca are then cloned to produce a nanobody library. Using this library, researchers perform rounds of screening to obtain target-specific nanobodies. The resulting nanobodies are expressed in bacterial systems.
To inquire about nanobody research platforms please contact Professor Wai-Hong Tham.
Antibodies are naturally occurring proteins produced by immune cells in response to invading microbes such as viruses.
Find out how we’re using antibody technologies to advance our research.