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Shene Chiou – Inflammation division

15/11/2024 2:00 pm - 15/11/2024 3:00 pm
Location
Davis Auditorium

WEHI PhD Completion Seminar hosted by Professor James Murphy & Dr Andre Samson

Shene Chiou

PhD Student – Murphy Laboratory, Inflammation division – Infection, Inflammation & Immunity Theme, WEHI

 

Necroptosis signaling in mouse models of testicular degeneration and inflammatory bowel disease

 

Davis Auditorium

Join via SLIDO enter code #WEHIphdcompletion

Including Q&A session

Followed by refreshments in Tapestry Lounge

 

 

 

Necroptosis is a pro-inflammatory programmed cell death pathway mediated by the kinases RIPK1 and RIPK3, and the MLKL pseudokinase. To dissect the roles of necroptosis in disease, including in testicular degeneration and inflammatory bowel disease (IBD), I developed new mouse strains that lacked MLKL or harboured catalytically-dead RIPK3. Contrary to earlier reports, injecting pro-necroptosis drugs in the mouse testis induced negligible levels of cell death. Unexpectedly, MLKL-deficiency caused elevated testosterone abundance, thus identifying a new function for MLKL. In two mouse models of IBD, MLKL-deficiency either rescued or worsened pathology, emphasising the context-dependent roles of MLKL in health and disease.

 

Shene completed a Bachelor of Science with Honours at the Department of Pharmacology, University of Melbourne in 2019. Her love for anatomy and physiology started with an Honours project at the Neurotrauma and Neurodevelopmental lab under Prof Norman Saunders. After honours she jumped from looking at how a maintenance drug used by patients with Bipolar disorder is distributed in foetal rat central nervous system to how necroptotic proteins are distributed and contribute in mouse models of diseases.

 

All welcome!

 

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