WEHI ACRF Cancer Biology and Stem Cells Special Seminar hosted by Professor Kate Sutherland

Roderik Kortlever

Research Fellow – Evan Laboratory of Cancer Biology, Francis Crick Institute & King’s College of London, UK

Myc programmes divergent innate immunity dictating tumour fate

 

Davis Auditorium

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Including Q&A session

Please note this presentation will not be recorded

Roderik obtained his PhD in the lab of René Bernards at the Netherlands Cancer Institute in Amsterdam, where he uncovered microenvironmental control by oncogenes and tumour suppressors. He pursued his post-doctoral studies in the lab of Gerard Evan – first in San Francisco, then at the University of Cambridge, and currently at the Crick in London. He discovered that oncogenic Myc collaborates with KRas in lung tumour progression by directly programming inflammation and immune suppression. His current research aims to elucidate the mechanisms driving tumour regression through the interplay of Myc, homeostatic immunity, and tissue regeneration.

In his seminar, he will showcase—using switchable genetic mouse models of lung cancer—how both the activation and inactivation of oncogenic Myc directly programme distinct innate immune responses typically associated with the initial phase of wounding versus the subsequent processes of regeneration and resolution. The findings provide a framework for exploiting endogenous tissue repair mechanisms in targeted cancer therapy through the rational, direct induction of tumour resolution.

All welcome!