WEHI PhD Completion Seminar hosted by Professor Wai-Hong Tham

Jaison D Sa

PhD Student – Tham Laboratory, Infection and Global Health division, WEHI

Characterisation of nanobodies and stabilised variants to progress antibody-based interventions and serodiagnostic development for Plasmodium adhesins

 

Davis Auditorium

Join via TEAMS

Including Q&A session

Followed by refreshments in Tapestry Lounge

Malaria is one of the deadliest parasitic diseases globally. Parasite survival relies on blood cell invasion which is mediated by interactions between Plasmodium adhesins and human receptors. In this study, I generated nanobodies targeting Plasmodium adhesins to block parasite invasion. Plasmodium adhesins are also targets of naturally acquired immunity. I employed computational protein design and protein expression approaches to create a stabilized Plasmodium adhesin which retained immune recognition, supporting its potential use as a serodiagnostic tool. These findings contribute to the development of antibody-based interventions and diagnostics against Plasmodium adhesins.

All welcome!