WEHI Special Proteomics Facility seminar hosted by Dr Laura Dagley
 

Hamish Stewart

Senior Staff Scientist – Thermo Fisher Scientific Bremen

 

Orbitrap Astral MS –  Technology Through to Discovery

 

Davis Auditorium
Join via TEAMS
Including Q&A session

Hamish Stewart is a Senior Staff Scientist at Thermo Fisher Scientific Bremen. He is the lead scientist for the Orbitrap Astral project and a developer of Orbitrap instrumentation, responsible for research on future commercial mass spectrometers, novel related concepts and technologies. Previously, he obtained his PhD in Physical Chemistry from the University of Nottingham and then worked for Shimadzu Research Laboratory (Europe) Ltd. He is the holder of 65 patents and is the winner of The George N Hatsopoulos Technical Innovation Award.

The great arc of mass spectrometer development has been to generate deeper analysis, faster, and with less input material. The evolution of instrumentation has been drastic and turbulent, with entire new analyzer classes emerging to prominence, declining and rising again over the last decades. The Thermo Scientific™ Orbitrap™ Astral™ mass spectrometer represents a coming of age of multi-reflection analyzers, combining multiple novel technologies that together grant its Astral analyzer order of magnitude level improvement in MS/MS sensitivity, speed and resolution over typical Orbitrap analysis. In parallel to this MS/MS analysis, a paired Orbitrap analyzer dedicates itself to generating high resolution, high accuracy panoramic full-MS spectra. 

In this seminar, the core technologies of the Astral analyzer are introduced and assessed, while the overall structure and operation of the hybrid Orbitrap Astral mass spectrometer is described. The application to producing record breaking depth at speed for both high throughput omics measurements and the expanding field of single cell analysis is explained and demonstrated, while key examples of recent published research enabled by the technology are highlighted.
 

All welcome!