WEHI Ubiquitin Signalling Special Seminar hosted by Professor David Komander

Dr Zhong Yan Gan
MRC Laboratory of Molecular Biology, UK

 

Understanding the mechanisms of membrane protein insertion and assembly

Davis Auditorium

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Including Q&A session

The human genome encodes more than 20,000 proteins, approximately 25% of which are integral membrane proteins. Work over multiple decades have revealed mechanisms underlying membrane protein targeting and insertion into the ER membrane. However, how multi-pass membrane proteins, which span the membrane multiple times, are inserted is still being clarified. Furthermore, a large proportion of integral membrane proteins assemble into and function as multi-subunit complexes. The mechanisms involved in complex assembly is poorly understood. In this talk, I will present ongoing work investigating the co-translational insertion of multi-pass membrane proteins and discuss my attempts at identifying new factors involved in the assembly of multi-subunit membrane protein complexes.

Zhong Yan Gan is an EMBO Postdoctoral Fellow with Dr Ramanujan Hegde at the MRC Laboratory of Molecular Biology in Cambridge, UK. In 2023, he completed his PhD at WEHI supervised by Prof David Komander and Prof Grant Dewson, where he studied the Parkinson’s disease-associated kinase PINK1.

All welcome!