WEHI Special Immunology Seminar hosted by Professor Misty Jenkins

Dr Nathaniel Dasyam

Research Fellow in the CAR T-cell Group, Malaghan Institute of Medical Research, NZ

Functional, transcriptomic and genomic characterisation of CD19-directed CAR T-cells incorporating a TLR2 co-stimulatory domain

Davis Auditorium

Join via TEAMS

Including Q&A session

Dr Nathaniel Dasyam completed his undergraduate studies as well as a PhD in Molecular Microbiology at Victoria University of Wellington. He has previously worked as a development scientist in a biotech company, Aroa Biosurgery, Auckland, New Zealand, where he contributed to the medical device development programme.  Dr Dasyam then moved to the Malaghan Institute of Medical Research, Wellington, New Zealand, where he is currently a Research Fellow in the CAR T-cell group led by Dr Robert Weinkove. He is responsible for conducting and overseeing laboratory assays to capture exploratory end-points of New Zealand’s first CAR T-cell clinical trial (ENABLE NCT04049513), and aiding the CAR T GMP team to optimise product release testing processes. He is also involved in mechanistic studies to characterise the molecular pathways of the current clinical CAR T-cell construct. This includes: molecular cloning, mammalian cell culture to generate lentivirus and CAR T cells, immune functional assays, and transcriptomics.

Dr Dasyam is also driving a project to identify the genetic location of transgenes in CAR T-cells, using long read sequencing methods, supported by the Maurice and Paykel trust and KiwiNet Emerging innovator funding. He is heavily involved in analyses of high dimensional data using online tools/ GUI based tools such as OMIQ, Cytoscape, Metascape as well as the statistical coding programme, R.

All Welcome!