WEHI Wednesday Seminar hosted by Professor Peter Czabotar
 

Dr Nadia Kershaw

Laboratory Head – Structural Biology division, WEHI

Structural and Biochemical studies on the Thrombopoietin Receptor

 

Davis Auditorium

Join via SLIDO enter code #WEHIWednesday

Including Q&A session
 

The Thrombopoietin Receptor is the primary regulator of megakaryopoiesis and subsequent platelet production, as well as playing a crucial role in maintenance of hematopoietic stem cells in the bone marrow. Consequently, a number of hematological disorders can arise through both loss and gain of function mutations in this pathway.

This seminar will describe recent studies on the Thrombopoietin Receptor, including elucidation of the cryo-EM structure of the extracellular domains in complex with Thrombopoietin, modelling of drug-receptor interactions, and investigations into novel functional regions of the intracellular domain. 

All welcome!