Dr Fei Wang is a research officer and bioinformatician in the Population Health and Immunity Division at WEHI. Her research focuses on understanding the genetic basis of various human traits and diseases through statistical analyses of large-scale genetic and biological data. Fei’s current work is concentrated on neurodegenerative disorders, with an emphasis on investigating the genomic determinants of Parkinson’s disease (PD) and dementia. Fei has extensive experience in bioinformatics tool development, variant curation, and statistical genetics.
In 2022, Fei commenced the Parkinson’s Pathway Molecular Data Analysis Program, funded by the Michael J. Fox Foundation and led by Professor Melanie Bahlo. Within this research program, Fei developed a bioinformatics tool called mitoCN, which estimates mitochondrial DNA copy number (mtDNA-CN) using whole-genome sequencing data. By applying this tool to one of the largest biorepositories for PD, she examined the association and potential causality between blood mtDNA-CN and PD, highlighting the role of peripheral inflammatory immune responses in the disease’s pathology.