WEHI Special ACRF Cancer Biology & Stem Cells seminar hosted by Professor Kate Sutherland

Associate Professor Andrew Cox
Dame Kate Campbell Fellow
Victorian Cancer Agency Mid-Career Research Fellow
Laboratory Head, Organogenesis and Cancer Program, Peter MacCallum Cancer Centre
Principal Research Fellow, Department of Biochemistry and Pharmacology, The University of Melbourne

Exploring cancer metabolism through the lens of developmental biology
 

In-person presentation

Davis Auditorium

Including Q&A session

Alterations in cellular metabolism are a defining feature of cancer. Growing evidence suggests that oncogenic transcription factors drive these metabolic transitions to support tumour initiation and progression. Yet, the precise mechanisms underpinning metabolic reprogramming remain poorly understood. Our laboratory has integrated advanced imaging, metabolomic, and transcriptomic approaches in zebrafish models of liver cancer. Using these approaches, we have discovered fundamental mechanisms by which YAP and NRF2 reprogram metabolism to control growth. Here, we will discuss some of the latest insights into these oncogenic pathways and their involvement in cell plasticity and cancer associated cachexia.

Associate Professor Andrew Cox earned his received his PhD from the University of Otago, New Zealand. He then undertook postdoctoral training at Harvard Medical School. In 2016, Dr Cox became a group leader in the Organogenesis and Cancer Program at the Peter MacCallum Cancer Centre and holds a joint appointment in the Department of Biochemistry and Pharmacology at the University of Melbourne. His laboratory uses zebrafish as a model system to elucidate pathways involved in liver regeneration and liver cancer. A central theme of his work is to understand how molecular pathways reprogram metabolism to fuel growth. Andrew has been the recipient of fellowships from the American Liver Foundation, the NHMRC, and the Victorian Cancer Agency.

All Welcome!