WEHI Wednesday Seminar hosted by Professor Daniel Gray

Associate Professor Jason Tye-Din
Laboratory Head – Immunology division, WEHI

Advancing a translational pipeline in coeliac disease

 

Davis Auditorium

Join via SLIDO enter code #WEHIWednesday

Including Q&A session
 

Effectively moving from scientific discovery to patient care is complex, and coeliac disease presents unique opportunities and challenges for translation. Our collaborative research program in coeliac disease began by understanding unmet patient needs and has progressed to leveraging T cell biology discoveries to develop and test novel diagnostic and therapeutic approaches. Lessons from a failed tolerogenic immunotherapy trial and our discovery of interleukin-2 in coeliac disease pathophysiology has informed a broad research program, including the development of a novel blood-based diagnostic, investigating the mechanistic basis of gluten-induced symptoms, using omics to understand gluten-specific T cells and defining the global reference standard for the gluten free diet. A key advantage of our platform is its adaptability, which we are now applying to the study of food-driven and other immune-mediated diseases. Our program’s multidisciplinary approach, engaging academic and clinical colleagues, industry, patient advocates, and regulatory bodies, is one exemplar for how translational research can be purposefully structured to deliver better outcomes for people living with this common autoimmune illness.

Jason Tye-Din is a Laboratory Head in the Immunology Division at WEHI and a gastroenterologist at the Royal Melbourne Hospital. His research team are focused on delivering translational outcomes for patients with gastrointestinal immune diseases, particularly coeliac disease.

All welcome!