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WEHI has research projects in cancer, immunology and infectious diseases, feeding into our robust discovery and development pipeline. We are committed to the translation of our discoveries into improvements in disease diagnosis, prevention and treatment.
Project name | Theme | Stage | Modality |
---|---|---|---|
Hit-to-Lead | Cell therapy | ||
Target Validation | Small molecule | ||
Target Validation | Gene therapy | ||
Hit Discovery | Biologics | ||
Target Validation | Biologics | ||
Target Validation | Small molecule | ||
Target Validation | RNA technology | ||
Target Validation | Biologic | ||
Target Validation | Cell culture system | ||
Lead Optimisation | Small molecule | ||
Lead optimisation | Small molecule | ||
β-prototype | Diagnostic | ||
Hit-to-Lead | α-prototype | ||
Hit-to-Lead | Small molecule | ||
β-prototype | Device |
A DC subset with superior antigen-presenting capability, engineered with a proprietary CAR design for immunotherapy.
Synthetic lethal targeting of MARCH5 to enhance Venetoclax efficacy.
Delivery of a cancer-selective mRNA therapeutic that targets APOBEC enzymes.
A new therapy for global prevention of hemolytic disease of the newborn
Method to induce stem-like memory T cells for long-lived response in vaccine design
Degradation of c-Rel for treating chronic autoimmune inflammatory disease.
Targeting negative regulators of inflammatory cytokine signalling in autoimmune disease.
Developing a first-in-class, anti-NINJ1 therapy for cell death associated diseases.
A media cocktail and culture system for in vitro human haematopoiesis.
Oral therapeutic targeting diverse coronavirus PLpros; potential to minimise progression to severe disease and post-acute sequelae of COVID-19 (PASC / Long COVID).
Oral therapeutic targeting coronavirus Mpro; potential to minimise progression to severe disease and post-acute sequelae of COVID-19 (PASC / Long COVID).
A high throughput diagnostic for relapsing liver malaria.
A high-throughput laboratory-based diagnostic for detecting hidden or cryptic liver stage Plasmodium vivax infections.
Using an epigenetic approach to turn on genes, the absence of which causes Prader Willi Syndrome, a devistating neurodevelopment disorder
An effective and affordable plunge freezing device for cryogenic electron microscopy.