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Yanxiang Meng

Illuminating cell death pathways and beyond 

A proud WEHI alumnus, Dr Yanxiang Meng’s future shines brightly as the recent recipient of the prestigious Stephen Wilkins Medal for his outstanding contributions to the field of structural biology and X-ray crystallography. Dr Meng’s journey from postdoc structural biologist to his current role as an R&D scientist at a biotech startup is testament of the transformative power of research and innovation.

The Australian Synchrotron Stephen Wilkins Thesis Medal is awarded to the PhD graduate with the best thesis using ANSTO facilities in their research. Dr Meng’s research at WEHI and the University of Melbourne focused on unravelling the molecular mechanisms behind a form of programmed cell death that plays a role in the development of a range of inflammatory diseases.

By using synchrotron techniques, including macromolecular crystallography and small-angle X-ray scattering, Dr Meng, was able to map for the first time the structural complexities of RIPK3-mediated necroptosis in human cells.

The Australian Synchrotron played a pivotal role in his structural biology studies. Dr Meng harnessed the power of the MX1 and MX2 beamline for X-ray crystallography studies, solving four novel co-crystal structures of protein complexes central to necroptosis. The SAXS/WAXS beamline allowed him to explore the makeup of these protein complexes in solution, shedding more light on the intricate molecular dance of cell death.

Dr Meng’s investigation into necroptosis and the activation mechanism of the MLKL protein has unveiled critical checkpoints within the cell death pathway. His findings provide essential insights into the detailed activation mechanism and structural relationships between the proteins MLKL and RIPK3.

By demystifying the molecular processes underpinning necroptosis, his work lays the foundation for potential therapies to treat diseases arising from the dysregulation of this cellular security system. Understanding how MLKL switches from an inactive to an activated state opens avenues for targeted treatments, offering hope for patients suffering from inflammatory diseases.

“The understanding of the molecular processes underpinning necroptosis is crucial because, by knowing how the security system operates, we can better find ways to control it if it malfunctions,” he said.

“In essence, the researchers have decoded some of the signals and sequences in this security system, which can pave the way to potential therapies to treat diseases that arise when the system goes haywire.”

Meng’s leap into biotech innovation

Dr Meng’s scientific career extends beyond the lab bench. After completing his project on necroptosis at WEHI, he transitioned to IonOpticks, a biotech company born out of the WEHI proteomics facility.

As an R&D scientist, he channels his expertise into developing innovative nanoflow chromatography technology for high-end proteomics applications. This move reflects his commitment to research translation and commercialisation, skills he believes are integral to turning scientific knowledge into products with tangible values.

Dr Meng’s journey from a postdoc at WEHI to a Stephen Wilkins Medal recipient and an R&D scientist at a biotech startup exemplifies the transformative impact of structural biology and synchrotron research. His work not only deepens our understanding of cell death pathways but also holds the promise of future therapies for inflammatory diseases.

From left: Simon Wilkins, Linda Wilkins, Dr Yanxiang Meng and the director of ANSTO Professor Michael James. 
Above: From left: Simon Wilkins, Linda Wilkins, Dr Yanxiang Meng and the director of ANSTO Professor Michael James.

WEHI wonders

When asked about his experience at WEHI he highlighted the vibrancy of the community of like-minded scientists and the many friendships he made.

“These connections are not just professional but also lasting friendships,” he said.

“It’s always nice to catch up with them and share our experiences, whether it’s about science, career, or life in general. Comparing our journey within and outside WEHI gave me lots of insights and inspirations for the direction I want to take in my future scientific career.’

Yinxiang Meng
Above: © ANSTO. From left: director of ANSTO Professor Michael James and Dr Yanxiang Meng

Beyond the lab

Dr Meng’s interests are not confined to the laboratory. Originating from the picturesque South Island of New Zealand, he loves getting back to nature and into the great outdoors. Feeling at home in the mountains, Meng is a passionate skier. However, when it is no longer snowing, he has also been learning how to surf.

Before embarking on his scientific career, Dr Meng worked in the wine industry. While his career may have taken a different trajectory, his passion for wine persists, manifesting in the appreciation of a fine glass, and recently extending into the realm of whisky connoisseurship.

Dr Meng also finds solace in the fantastical worlds crafted by Andrzej Sapkowski in the Witcher series. Currently engrossed in Time of Contempt, he immerses himself in these realms against a melodic backdrop of jazz and bossa nova.

Connect with Yanxiang on LinkedIn

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