Why is interleukin-11 elevated in acute myeloid leukaemia?

Why is interleukin-11 elevated in acute myeloid leukaemia?

Project details

Acute myeloid leukaemia (AML) is a cancer that affects the blood and bone marrow, resulting in an overproduction of immature while blood cells. This is an aggressive disease, with current treatments depending on the age of the patient, and the sub-type of AML. In order to improve treatment outcomes, it is important to better understand how the disease progresses. We are particularly interested in a cytokine, called interleukin-11, which has previously been linked to AML; however, its function within this disease remains unknown.

In this project, we will use a number of state-of-the-art imaging and modelling systems together with biochemical and functional analysis of signalling pathways.

 

About our research group

This is a collaborative project, taking advantage of the skills developed by a team of scientists with expertise in leukaemia models, clinical leukaemia management and the development of biologics for clinical use. The student and project will benefit from additional collaborations with the Peter MacCallum Cancer Centre, Murdoch Children’s Research Institute, and CSL Ltd. 

Researchers:

Gabriela Brumatti profile photo
Dr
Gabriela
Brumatti
Cell Signalling and Cell Death division

Dr Tracy Putoczki

Tracy Putoczki
Dr
Tracy
Putoczki
Laboratory Head

Project Type: