Understanding the neuroimmune regulation of innate immunity

Understanding the neuroimmune regulation of innate immunity

Project details

The discovery of innate lymphoid cells (ILCs) has forced immunologists to rethink how the immune system provides tissue protection. Our pioneering work revealed that ILCs not only react to pathogens but also actively regulate the function of the organs in which they reside.

In the gut, ILCs interact with neurons to sense food intake which promotes protective immunity against invasive micro-organisms, while at the same time fostering nutrient uptake (Seillet, Nature Immunology, 21(2), 168).

This project aims to identify new neuronal regulators of ILCs and the environmental factors influencing these neuroimmune communications. This research will involve cutting-edge approaches in cellular culture, flow cytometry, 3D imaging and single cell RNA sequencing.

About our research group

Our immune system needs to balance the competing goals of protecting us from invading micro-organisms, while at the same time remaining tolerant to our own cells and the multitude of helpful bacteria that reside in our bodies. Research in our group aims to understand how the immune system is set up, how the many specific types of white blood cells function together to provide protective immunity and what goes wrong in conditions such as autoimmunity, inflammation and allergy. The lab consists of a mix of PhD students and post-doctoral fellows and uses both cellular and molecular techniques to investigate these questions.

 

Email supervisors

 

Researchers:

Dr Cyril Seillet
Dr
Cyril
Seillet
Immunology division

Project Type: