Understanding the molecular basis of chromosome instability in gastric cancer

Understanding the molecular basis of chromosome instability in gastric cancer

Project details

Gastric cancer is major public health problem. Many gastric cancers present with highly rearranged genomes, a phenomenon known as chromosome instability. Cancers with chromosome instability show worse outcomes and tend to respond worse to chemotherapy.

This project will study the molecular basis underlying chromosome instability in gastric cancer. Work will involve the use of various molecular biology techniques, model systems and the analysis of patient cancer specimens. Results will provide fundamental insights into the mechanisms that govern human gastric cancer growth, and may open novel therapeutic opportunities.

About our research group

My research group has a major focus on bowel and stomach cancer genomics, the application of high-throughput molecular profiling technologies to identify principal cancer genes and biomarkers of cancer risk and prognosis. We are conducting next-generation sequencing and microarray studies involving large patient cohorts to define molecular signatures associated with tumour characteristics and outcome.

Patient-focused investigations are being complemented with functional studies on cancer cell lines to distinguish driver from passenger mutations and to gain insights into molecular pathways of carcinogenesis. Molecularly-annotated cancer cell lines are further being used to explore the efficacy of novel drug therapies, both as single-agents and in combination with standard therapies.

 

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