TNF-induced inflammation, inflammatory bowel disease and colon cancer

TNF-induced inflammation, inflammatory bowel disease and colon cancer

Details of project

Tumour necrosis factor (TNF) is a major inflammatory mediator. Excessive levels of TNF are linked to many diseases including rheumatoid arthritis (RA), Crohn’s disease (CD), ulcerative colitis (UC), heart valve disease and cancer. Our research is aimed at understanding how TNF expression is regulated, with the hope that we can use this knowledge to manipulate TNF expression for therapeutic purposes.

TNF plays many functions in immunity, inflammation, cell proliferation and cell death. For this reasons, its role in cancer is ambiguous. Thus, we also investigate the influence of TNF-associated chronic inflammation on the development and the therapy of cancer.

The project will utilise in vitro and in vivo models, and a variety of cell and molecular biology techniques including CRISPR, tissue culture and protein chemistry.

About our research group 

The focus of the Bouillet lab is to understand fundamental processes of inflammation and their deregulation in disease. Dr Maree Faux, who works within the Burgess lab, is investigating the biology and biochemistry of bowel cancer, with the aim of discovering new strategies to prevent and treat it.


Dr Maree Faux
Structural Biology division

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