The role of hypoxia in cell death and inflammation

The role of hypoxia in cell death and inflammation

Project details

Hypoxia is present in many pathological situations, including cancer and wounds. The inflammatory cytokine TNF also plays a role in these situations, and we have recently shown that ADO – an enzyme that is critical for regulating the levels of proteins during hypoxia – (Masson, Science 2019 365:65) also plays a role in regulating TNF=induced cell death (Kearney, Sci Immunol 2018 eaar3451). Despite the physiological relevance of oxygen concentration, most lab experiments are performed at super-normal concentrations, most probably leading to an erroneous view of many signalling pathways. This project will explore the role of hypoxia and normoxia in signalling pathways important in the wound response and tumorigenesis.

Students will learn general molecular biology, tissue culture and protein biochemistry techniques. 

About our research group

Our lab is an international, multi-disciplinary group with a stimulating and supportive mix of post-docs, PhD students and research assistants (~10 people). Similarly, there is a broad mix of projects ranging from purely academic to commercially focused. Working in this environment exposes students to a wide range of experiences that enable them to develop their career post-PhD in a way that suits their own career aspirations. This project is solely academic (most appropriate for a PhD). Many PhD students from our lab have gone on to do post-docs in top European labs.


Email supervisors



Professor John Silke

John Silke
Laboratory Head; Leader, Infection, Inflammation and Immunity Theme

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