Reconciling intracellular imaging and metastatic behaviour in cancer cells

Reconciling intracellular imaging and metastatic behaviour in cancer cells

Project details

Advances in labelling methods, imaging technologies and computational strategies are allowing cellular structure and function to be interrogated with unprecedented detail (Chen et al. Science, 2014, 346, 1257998).

In this study, we will use cutting-edge 4-dimensional (3D + time) microscopy techniques, including multi-spectral imaging, lattice light sheet and live cell super-resolution microscopy to study the organelle interactome in live tumour cells (Valm et al. Nature 2017, 546, 162-167). This systems-level approach should provide greater insight into how the behaviour of sub-cellular structures differs for tumours harbouring different metastatic potential, as organelle contacts have been shown to have a vital role in diverse cellular functions (Rowland, A. A., et al. Cell, 2014, 159, 1027–1041, Friedman, J. R. et al. Science  2011, 334, 358–362). 

About our research group

My laboratory is located within the Institute's imaging facility. Our state-of-the-art microscopy equipment includes three-dimensional views of cell and tissue structure or preclinical imaging systems to perform in vivo imaging.

This project will be done in collaboration with Dr Delphine Merino,  head of the Tumour Progression and Heterogeneity laboratory at the Olivia Newton-John Cancer Research Institute, who has access to various tumour models from patients and cancer cell lines.

 

 

Researchers:

Dr Kelly Rogers

Dr Kelly Rogers
Dr
Kelly
Rogers
Head, Imaging Laboratory
Dr Delphine Merino
Dr
Delphine
Merino
Olivia Newton-John Cancer Research Institute

Project Type: