Plasmodium vivax host-parasite interactions: impact on immunity

Plasmodium vivax host-parasite interactions: impact on immunity

Project details

Malaria is an infectious disease caused by the parasite Plasmodium. Outside of Africa, the species P. vivax is a major threat to elimination due to specific features of this parasite, such as an arrested liver-stage. We aim to understand host-parasite interactions of P. vivax, and how this impacts the development of naturally acquired immunity. Using human samples from endemic areas we will map immune responses and relate them to host genetics with the aim to identify risk and protection factors. 

This project will use a variety of immunological and genomic techniques to determine the impact of both host and parasite genetics on the development of clinical immunity to P. vivax. You will learn techniques such as multiplex ELISA, second and third-generation sequencing, bioinformatics, and parasite culture, among others.  

About our research group

The Mueller laboratory is part of the Population Health and Immunity division and currently includes four postdoctoral fellows, two PhD students, one Honours student, one Masters student, two clinicians and one research assistant based at Parkville, and an additional three postdoctoral fellows and two PhD students based overseas. Collectively, we have a wide range of expertise in immunology, molecular biology, epidemiology, genomics, statistics and modeling. Dr Charnaud leads the molecular projects and Dr Longley leads the immunological projects. 

We have a strategic network of national and international collaborators, and actively conduct field epidemiology studies with our partners in Thailand, Brazil, Papua New Guinea, Cambodia and the Solomon Islands. Our groups’ ultimate goal is to contribute to malaria elimination programs. 

 

Researchers:

Dr Sarah Charnaud profile photo
Dr
Sarah
Charnaud
Population Health and Immunity division
Rhea Longley profile
Dr
Rhea
Longley
Population Health and Immunity division

Professor Ivo Mueller

Professor Ivo Mueller
Professor
Ivo
Mueller
Joint Division Head

Project Type: