Optimising serological markers of recent exposure to Plasmodium vivax

Optimising serological markers of recent exposure to Plasmodium vivax

Project details

Malaria is an infectious disease caused by the parasite Plasmodium. Renewed intensification of global malaria control efforts over the past 10 years has had significant success, however, key challenges remain to achieve elimination. Our research group has addressed one key challenge – the development of better surveillance methods for countries aiming for malaria elimination. We have exploited the host response to malaria infections by identifying proteins that induce antibody responses that are indicative of recent malaria infections.

We are now aiming to further optimise the proteins sequences of these markers, including analysis of potential cross-reactivity between different Plasmodium species. This project will involve immunological techniques, data analysis including spatial mapping, and work with international collaborators.

About our research group

The Mueller laboratory is part of the Population Health and Immunity division and currently includes eight postdoctoral fellows, two PhD students, one clinician and two research assistants based at Parkville, and an additional two postdoctoral fellows and two PhD students based overseas. Collectively, we have a wide range of expertise in immunology, molecular biology, epidemiology, statistics and modeling. 

We have a strategic network of national and international collaborators, and actively conduct field epidemiology studies with our partners in Thailand, Brazil, Papua New Guinea and the Solomon Islands. Our group's ultimate goal is to contribute to malaria elimination programs.

Researchers:

Rhea Longley profile
Dr
Rhea
Longley
Population Health and Immunity division

Professor Ivo Mueller

Professor Ivo Mueller
Professor
Ivo
Mueller
Joint Division Head

Project Type: