Novel tool for malaria surveillance and intervention

Novel tool for malaria surveillance and intervention

Project details

As malaria transmission continues to decline, even the most sensitive methods for determining prevalence via detection of the parasite become inefficient and the need to identify individuals at risk of Plasmodium vivax relapse from hypnozoites increases. Antibodies that accurately predict recent exposure allow identification and treatment of individuals harbouring P. vivax hypnozoites and facilitate discrimination between areas of ongoing local transmission from those where it has been interrupted.

By applying novel serological markers of exposure in a trial in Papua New Guinea, we aim to:

  1. Determine the efficacy of a serological screening and treatment (SSAT) intervention for P. vivax elimination; and
  2. Compare the performance of these novel serological markers with classical epidemiological and state-of-the art molecular markers for identification of ‘hot-spots’ of recent transmission. 

About our research group

The Robinson and Mueller groups conduct epidemiological studies and trials in malaria endemic countries to better understand how parasites and hosts interact so as to inform the development and implementation of effective, evidence-based public health programs that will accelerate the elimination of malaria. All studies and trials combine detailed molecular and immunological components with in-depth epidemiological analyses and mathematical modelling. Our groups collaborate very closely with the PNG Institute of Medical Research, Burnet Institute as well as numerous other groups elsewhere in Australia, Europe and the US.

 

Researchers:

Dr Leanne Robinson

Dr Leanne Robinson in Papua New Guinea
Dr
Leanne
Robinson
Laboratory Head

Professor Ivo Mueller

Professor Ivo Mueller
Professor
Ivo
Mueller
Joint Division Head

Project Type: