Molecular mechanism underpinning dendritic cell ontogeny and functions

Molecular mechanism underpinning dendritic cell ontogeny and functions

Project details

Dendritic cells (DCs) are professional antigen-presenting cells, located throughout the body. They form the first line of defence against pathogens. To provide this protection DCs have evolved into specialised subsets that perform unique functions. Our research aims to understand the molecular mechanisms underpinning DC diversity as these studies will pave the way to uncover novel approaches to alter DC fate to tailor DC-based therapeutic approaches.

The current project stems from our combined genomic and functional approaches to draw a comprehensive molecular description of the DC programming landscape (Chopin et al. JEM 2013, Cell Reports 2016). 

Combining cellular, molecular biology, and high throughput technologies the candidate will investigate the role of novel transcription factors in governing DC fate.

 

About our research group

Our research aims to investigate how master regulators function on a cellular and molecular level to program the immune system. To address these questions, we use:

  • Genetics
  • High-throughput genomic technologies
  • Infectious disease models 
  • Cell culture 

Researchers:

Michael Chopin profile photo
Dr
Michael
Chopin
Molecular Immunology division

Project Type: