Modelling gene regulatory systems

Modelling gene regulatory systems

Project details

Cellular phenotypes are regulated by robust networks of molecules that control gene expression. These regulatory systems enable stable cell function under normal conditions and are frequently dysregulated in cancer. We understand parts of this regulatory network, such as the role of transcription factors in controlling gene transcription, however much work is still needed to understand the interconnected roles of transcription factors, chromatin architecture, epigenetic modification of DNA and non-coding RNAs. This project will build on our existing work (Cursons, Cell Systems 2018 7(1):77) to develop integrated models of these complex regulatory networks.  

Students will develop skills in bioinformatics and computational analysis of large complex datasets, and an understanding of the systems biology of regulatory networks. 

About our research group

The Davis laboratory is a computational biology group which is focused on the analysis and reconstruction of regulatory systems that link genome, transcriptome, proteome and phenotype. Our work is focused on exploring mechanisms of cancer progression and response to therapy, including regulatory programs such as epithelial-mesenchymal transition. We have a general interest in how cancerous cells hijack various regulatory mechanisms that allow unregulated growth or confer the ability to metastasise and form new tumors. While our laboratory has an established breast cancer research program, we have a general interest in different cancer types. 


Dr Melissa Davis

Portrait photo of Dr Melissa Davis
Joint Division Head
Joe Cursons
Bioinformatics division

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