Mechanism and modulation of K+ channels and membrane transporters

Mechanism and modulation of K+ channels and membrane transporters

Project details

Potassium channels perpetuate electrical impulses in our central nervous system and facilitate cellular pathways, cell division and cell death processes. Aberrant channel activity has been linked to conditions including cardiovascular disease, diabetes, primary immunodeficiencies and cancer malignancy.

We offer a selection of hypothesis-driven projects addressing the still-elusive control and regulation of potassium currents. We have shown that pore conformation is not the single determining factor controlling function. Our specific focus is on resolving key mechanisms independent of pore conformation, with a long-term vision of developing selective, discriminatory K+ channel modulators. 

The projects involve protein expression and biochemistry, making point mutations, reconstitution of ion channels into bilayer environments, functional assays and interaction with collaborators. 

Projects investigating mitochondrial protein translocation machinery are also available.

 

About our research group

Our group focuses on specific membrane transport machinery, using structural, biochemical and biophysical methods to study mechanism of ion channels and mitochondrial translocases. Key collaborators have expertise in electrophysiology (Derek Laver), Molecular Dynamics (Brian Smith), Fly Genetics (Leonie Quinn) and Mitochondrial Translocases (Diana Stojanovski).

The group currently includes two PhD students and a postdoctoral researcher integrated into a vibrant divisional laboratory with an emphasis on cross-pollination of ideas.

Researchers:

Dr Jacqui Gulbis

Dr Jacqui Gulbis
Dr
Jacqui
Gulbis
Laboratory Head

Project Type: