Mechanics of T cell receptor activation

Mechanics of T cell receptor activation

Project details

The T cell antigen receptor (TCR) occupies a central role in vertebrate adaptive immunity. The mechanism by which it transmits information about the antigenic environment within the body represents a crucial unresolved problem in T cell biology. 

The receptor comprises eight separate protein subunits that must work in concert to convert extracellular ligand binding into intracellular biochemical signals. 

This project capitalises on our recent discovery that the membrane-embedded portion of the receptor is organised around a highly conserved core structure and focuses on understanding the relationship between this structure and receptor function. 

A student involved in this work will gain expertise in a variety of molecular and cellular immunology techniques and learn about important signalling pathways in T cell-mediated immunity. 

About our research group

Research in the Call lab is co-directed by Matthew and Melissa Call and focuses on understanding the basic mechanisms of transmembrane signalling by cell-surface receptors in immunity and haematopoietic development.

We apply a broad range of biochemical, biophysical (X-ray crystallography, solution NMR) and cell-biological techniques to study receptor structure, function and regulation from the atomic scale to in vivo settings. Our interests thus combine the fields of membrane protein structural biology and molecular immunology, and members of the lab receive strong training in either or both of these areas.


Dr Melissa Call

Dr Melissa Call in her office
Laboratory Head

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