Investigating new paths to selective modulation of potassium channels (Masters option available)

Investigating new paths to selective modulation of potassium channels (Masters option available)

Project details

Although widely appreciated for the essential role they play in electrical signalling, potassium (K+) channels are also crucial determinants of cellular calcium and cell cycle progression. They facilitate neural transmission, cell messaging, organ function, immunity, cell proliferation, cell death and tumour progression. Aberrant K+ channel activity is thus associated with a broad spectrum of disease. 

Our project(s) address underlying principles by which K+ channels are controlled and how mechanisms can be selectively implemented. Medium term objectives are to identify selective molecular tools for interrogating their cell biology and pathology, and in the longer term to open up avenues for treatment based on selective channel modulators. 

At a technical level, the projects involve protein expression, purification, biochemistry, structure analysis, reconstitution into bilayers and functional evaluation. 

About our research group

The group focuses on specific membrane transport machinery, using structural, biochemical and biophysical methods to study ion channels and mitochondrial protein translocases. We can offer projects in either area. We work with collaborators expert in electrophysiology, molecular simulations, fly genetics, mitochondrial translocases, native mass spectrometry and cryo-EM. 

 

Researchers:

Dr Jacqui Gulbis

Dr Jacqui Gulbis
Dr
Jacqui
Gulbis
Laboratory Head

Project Type: