Investigating mechanisms of innate immune activation

Investigating mechanisms of innate immune activation

Project details

The innate immune system is our primary defence mechanism to rapidly respond to microbial insults. Families of receptors expressed by specialised immune cells sense conserved microbial molecules culminating in the activation of specific transcription factors or proteolytic pathways to mediate an inflammatory response

Investigating how these pathways are activated and modulated is critical for a better understanding of non-resolving inflammation in chronic diseases, such as atherosclerosis and autoinflammatory disease. 

This project will utilise a range of cutting-edge molecular, cell biology and biochemical approaches (e.g. CRISPR/Cas9, viral transduction, confocal microscopy) in models of inflammation to investigate, dissect and discover mechanisms that control the activation and regulation of specific innate immune receptor pathways. 

About our research group

Dr De Nardo is a team member of the Masters lab, within the Inflammation division. His research focuses on better understanding the molecular mechanisms controlling the activation and regulation of innate immune receptors and signalling pathways, and their role in physiological and pathological inflammation. He recently discovered how high density lipoproteins mediate anti-inflammatory effects on immune cells (De Nardo et al, Nature Immunology, 2014) and identified a key regulator of type I interferon responses (Labzin et al, Journal of Immunology, 2015).


Dr Dominic De Nardo profile photo
De Nardo
Inflammation division

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