Investigating brain abnormalities with single cell ‘omics

Investigating brain abnormalities with single cell ‘omics

Project details

The presence of structural abnormalities in the brain is common in neurological diseases such as epilepsy and speech disorders. Abnormalities are also suspected to play a role in mental disorders like schizophrenia. New technologies allow us to investigate the individual molecular characteristics of a large number of cells. 

This project will harness the power of these technologies in order to examine single cells from abnormal brain tissue in terms of their genetic, epigenetic, transcriptomic and proteomic features. The student will work in close collaboration with clinicians and biologists in the Parkville Precinct and beyond. The student’s work will focus on data analysis and the development of new methods for the analysis of single cell data as well as appropriate visualisations.

About our research group

The Bahlo lab is a bioinformatics lab located in the Population Health and Immunity division, consisting of 12 staff and students, including two PhD students and one Masters student.

We have a strong interest in statistical and population genomics and transcriptomics with a concurrent interest in relevant statistical methods, working in close collaboration with a variety of genetic and clinical collaborators, both in malaria and neurological diseases.

This project will be based in the Bahlo lab, but will involve close collaboration with local collaborators, generating data from patients with neurological disorders with common brain abnormalities. The project requires a solid foundation in statistics and interest in brain biology. It would suit a student with a major in a statistical science or mathematics.



Professor Melanie Bahlo

Melanie Bahlo
Joint Division Head
Dr Saskia Freytag profile shot
Population Health and Immunity

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