Investigating apoptosis control in tumour blood vessels

Investigating apoptosis control in tumour blood vessels

Project details

As a tumour grows, its associated blood vascular network must expand with it to meet its increased oxygen and nutritional demands. Knowing how to prevent the expansion of the tumour-associated vascular network or remove existing vessels from a tumour may help block further tumour growth and even cause its regression. Blood vessel networks expand through a process termed ‘angiogenesis’: the growth of new vessels from pre-existing vessels.

This project will investigate the molecular and genetic basis of endothelial cell survival during angiogenesis.

Skills and techniques: This project will involve the following techniques: cell culture, tissue immunohistochemistry, advanced imaging and image analysis techniques.

About our research group

My laboratory uses cutting edge techniques to understand the molecular regulation of angiogenesis: the growth and remodelling of blood vessel networks (Coultas et al, Nature 2005 438:937-945). This process has a critical role in a number of diseases including cancer and eye disease such as age-related macular degeneration and diabetic retinopathy. There have been significant recent advances in our understanding of angiogenesis, yet much remains unknown about how this highly complex process works. My laboratory is interested in understanding the processes and pathways that govern angiogenesis during normal development, in particular the role for apoptosis (programmed cell death).

Further reading:

  • Watson et al, Cell Mol Life Sci 2017 doi: 10.1007/s00018-017-2577-y

  • Watson et al, Development 2016 143(16):2973

  • Watson et al, Cell Death Differ 2016 23(8):1371

  • Koenig et al, Cell Death Differ 2014 21(11):1687

Researchers:

Dr Leigh Coultas

Leigh Coultas
Dr
Leigh
Coultas
Laboratory Head

Professor Andreas Strasser

Andreas Strasser
Professor
Andreas
Strasser
Joint Division Head

Project Type: