Identification of genes critical for the control of chronic infections

Identification of genes critical for the control of chronic infections

Project details

Chronic infections are an enormous global health burden that are responsible for the morbidity and mortality of tens of millions of people every year. Examples of pathogens responsible for such scourges are Mycobacterium tuberculosis (TB), human immunodeficiency virus (HIV) and hepatitis B virus (HBV). Whilst vastly different pathogens, they all cause chronic disease that is characterized by an abject failure of the immune system to adequately control infection.

Projects are available that investigate the contribution of different genes to the development of robust immune responses during chronic infection. Specifically, we seek to identify genes that may help or hinder the host in clearing infection.

Students will become highly skilled in: understanding the kinetics and progression of chronic infections; propagating, handling and quantifying infectious material; isolating immune cells; gene manipulation techniques; practical problem-solving skills

About our research group

Our lab is interested in chronic infectious diseases, particularly from the perspective of the host. There are many unknowns that surround the failure of the immune system in this setting, which manifests as the death and/or dysfunction of immune cells.

We work on a range of dangerous yet fascinating pathogens, and have had great success in our highly novel endeavours to utilise different therapeutic agents to enhance the clearance of infected cells. We are also interested in coordinating these approaches with genetic or pharmacological strategies to prevent the premature death of immune cells. We believe that combinatorial approaches such as these will be essential for the cure or long-term remission of chronic infectious diseases, such as TB, HIV, and HBV.

 

 

Researchers:

Professor Marc Pellegrini

Professor Marc Pellegrini in the lab
Professor
Marc
Pellegrini
Joint Division Head

Project Type: