Genomic instability and the immune microenvironment in lung cancer

Genomic instability and the immune microenvironment in lung cancer

Project details

Non-small cell lung cancer is genetically unstable and exhibits one of the highest mutation rates of all cancers. Genetically unstable tumours have a high mutation burden and a better response to immunotherapy. However, only 20 per cent of patients respond to treatment and the biomarkers to predict this response are not well defined.

This project aims to better understand the interactions between genetically unstable tumour cells and the immune microenvironment to define biomarkers of response to immunotherapy. Experimental approaches will include development of a co-culture system where immune cells and tumour cells isolated are grown as multicellular organoids; multi-omic analysis of immune cells surrounding primary and metastatic cancer. Activated pathways identified through the multi-omic studies will be altered genetically or chemically in the organoid system to evaluate their impact on tumour growth and the relationship between genetic instability and immune response.

About our research group

The Asselin-Labat laboratory is interested in studying the cellular and molecular mechanisms underlying lung development, lung cancer formation and therapeutic response. We combine our expertise in lung stem cells and lung cancer to decipher pathways disrupted in lung disease. We take a multi-disciplinary approach to research and collaborate closely with immunologists, computational biologists, respiratory physicians and medical oncologists.

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